Cargando…
First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil
Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768515/ https://www.ncbi.nlm.nih.gov/pubmed/33287355 http://dx.doi.org/10.3390/idr12030021 |
_version_ | 1783629174816112640 |
---|---|
author | dos Santos, Anderson Lineu Siqueira Rodrigues, Yan Corrêa de Melo, Marcos Vinícios Hino Silva dos Santos, Pabllo Antonny Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Valéria Batista |
author_facet | dos Santos, Anderson Lineu Siqueira Rodrigues, Yan Corrêa de Melo, Marcos Vinícios Hino Silva dos Santos, Pabllo Antonny Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Valéria Batista |
author_sort | dos Santos, Anderson Lineu Siqueira |
collection | PubMed |
description | Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring bla(KPC-1) gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region. |
format | Online Article Text |
id | pubmed-7768515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77685152020-12-29 First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil dos Santos, Anderson Lineu Siqueira Rodrigues, Yan Corrêa de Melo, Marcos Vinícios Hino Silva dos Santos, Pabllo Antonny Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Valéria Batista Infect Dis Rep Communication Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring bla(KPC-1) gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region. MDPI 2020-12-03 /pmc/articles/PMC7768515/ /pubmed/33287355 http://dx.doi.org/10.3390/idr12030021 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication dos Santos, Anderson Lineu Siqueira Rodrigues, Yan Corrêa de Melo, Marcos Vinícios Hino Silva dos Santos, Pabllo Antonny Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Valéria Batista First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil |
title | First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil |
title_full | First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil |
title_fullStr | First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil |
title_full_unstemmed | First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil |
title_short | First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil |
title_sort | first insights into clinical and resistance features of infections by klebsiella pneumoniae among oncological patients from a referral center in amazon region, brazil |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768515/ https://www.ncbi.nlm.nih.gov/pubmed/33287355 http://dx.doi.org/10.3390/idr12030021 |
work_keys_str_mv | AT dossantosandersonlineusiqueira firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT rodriguesyancorrea firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT demelomarcosvinicioshino firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT silvadossantospablloantonny firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT oliveiratatyellennatashadacosta firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT sardinhadanielemelo firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT limaluananepomucenogondimcosta firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT brasiliensedaniellemurici firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil AT limakarlavaleriabatista firstinsightsintoclinicalandresistancefeaturesofinfectionsbyklebsiellapneumoniaeamongoncologicalpatientsfromareferralcenterinamazonregionbrazil |