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Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications

Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide r...

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Autores principales: Tsiakas, Stathis, Skalioti, Chrysanthi, Kotsi, Paraskevi, Boletis, Ioannis, Marinaki, Smaragdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768524/
https://www.ncbi.nlm.nih.gov/pubmed/33391773
http://dx.doi.org/10.1093/omcr/omaa117
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author Tsiakas, Stathis
Skalioti, Chrysanthi
Kotsi, Paraskevi
Boletis, Ioannis
Marinaki, Smaragdi
author_facet Tsiakas, Stathis
Skalioti, Chrysanthi
Kotsi, Paraskevi
Boletis, Ioannis
Marinaki, Smaragdi
author_sort Tsiakas, Stathis
collection PubMed
description Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement.
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spelling pubmed-77685242020-12-31 Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications Tsiakas, Stathis Skalioti, Chrysanthi Kotsi, Paraskevi Boletis, Ioannis Marinaki, Smaragdi Oxf Med Case Reports Case Report Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement. Oxford University Press 2020-12-28 /pmc/articles/PMC7768524/ /pubmed/33391773 http://dx.doi.org/10.1093/omcr/omaa117 Text en © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Tsiakas, Stathis
Skalioti, Chrysanthi
Kotsi, Paraskevi
Boletis, Ioannis
Marinaki, Smaragdi
Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
title Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
title_full Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
title_fullStr Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
title_full_unstemmed Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
title_short Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
title_sort case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768524/
https://www.ncbi.nlm.nih.gov/pubmed/33391773
http://dx.doi.org/10.1093/omcr/omaa117
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