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Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768524/ https://www.ncbi.nlm.nih.gov/pubmed/33391773 http://dx.doi.org/10.1093/omcr/omaa117 |
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author | Tsiakas, Stathis Skalioti, Chrysanthi Kotsi, Paraskevi Boletis, Ioannis Marinaki, Smaragdi |
author_facet | Tsiakas, Stathis Skalioti, Chrysanthi Kotsi, Paraskevi Boletis, Ioannis Marinaki, Smaragdi |
author_sort | Tsiakas, Stathis |
collection | PubMed |
description | Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement. |
format | Online Article Text |
id | pubmed-7768524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77685242020-12-31 Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications Tsiakas, Stathis Skalioti, Chrysanthi Kotsi, Paraskevi Boletis, Ioannis Marinaki, Smaragdi Oxf Med Case Reports Case Report Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement. Oxford University Press 2020-12-28 /pmc/articles/PMC7768524/ /pubmed/33391773 http://dx.doi.org/10.1093/omcr/omaa117 Text en © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Tsiakas, Stathis Skalioti, Chrysanthi Kotsi, Paraskevi Boletis, Ioannis Marinaki, Smaragdi Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
title | Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
title_full | Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
title_fullStr | Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
title_full_unstemmed | Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
title_short | Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
title_sort | case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768524/ https://www.ncbi.nlm.nih.gov/pubmed/33391773 http://dx.doi.org/10.1093/omcr/omaa117 |
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