Cargando…
The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, yet as of currently, there is no disease-modifying therapy that could delay its progression. Paeonia lactiflora Pall. is the most frequently used herb in formulas for PD in Traditional Chinese Medicin...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768820/ https://www.ncbi.nlm.nih.gov/pubmed/33381034 http://dx.doi.org/10.3389/fphar.2020.581984 |
_version_ | 1783629215454724096 |
---|---|
author | Du, Wanqing Liang, Xiao Wang, Shanze Lee, Philip Zhang, Yunling |
author_facet | Du, Wanqing Liang, Xiao Wang, Shanze Lee, Philip Zhang, Yunling |
author_sort | Du, Wanqing |
collection | PubMed |
description | Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, yet as of currently, there is no disease-modifying therapy that could delay its progression. Paeonia lactiflora Pall. is the most frequently used herb in formulas for PD in Traditional Chinese Medicine and also a potential neuroprotective agent for neurodegenerative diseases, while its mechanisms remain poorly understood. In this study, we aim to explore the underlying mechanism of P. lactiflora in treating PD utilizing a network pharmacology approach. Methods: The protein targets of P. lactiflora ingredients and PD were first obtained from several databases. To clarify the key targets, a Protein-Protein-Interaction (PPI) network was constructed and analyzed on the String database, and then enrichment analysis was performed by the Metascape platform to determine the main Gene Ontology biological processes and Kyoto Encyclopedia of Genes and Genomes pathways. Finally, the Ingredient-Target-Pathway (I-T-P) network was constructed and analyzed by Cytoscape software. Results: Six active ingredients of P. lactiflora (kaempferol, ß-sitosterol, betulinic acid, palbinone, paeoniflorin and (+)-catechin) as well as six core targets strongly related to PD treatment [AKT1, interleukin-6, CAT, Tumor necrosis factor (TNF), CASP3, and PTGS2] were identified. The main pathways were shown to involve neuroactive ligand-receptor interaction, Calcium signaling pathway, PI3-Akt signaling pathway, TNF signaling pathway, and apoptosis signaling pathway. The main biological process included the regulation of neurotransmitter levels. Conclusion: P. lactiflora may retard neurodegeneration by reducing neuroinflammation, inhibiting intrinsic and extrinsic apoptosis, and may improve motor and non-motor symptoms by regulating the levels of neurotransmitters. Our study has revealed the mechanism of P. lactiflora in the treatment of PD and may contribute to novel drug development for PD. |
format | Online Article Text |
id | pubmed-7768820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77688202020-12-29 The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach Du, Wanqing Liang, Xiao Wang, Shanze Lee, Philip Zhang, Yunling Front Pharmacol Pharmacology Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, yet as of currently, there is no disease-modifying therapy that could delay its progression. Paeonia lactiflora Pall. is the most frequently used herb in formulas for PD in Traditional Chinese Medicine and also a potential neuroprotective agent for neurodegenerative diseases, while its mechanisms remain poorly understood. In this study, we aim to explore the underlying mechanism of P. lactiflora in treating PD utilizing a network pharmacology approach. Methods: The protein targets of P. lactiflora ingredients and PD were first obtained from several databases. To clarify the key targets, a Protein-Protein-Interaction (PPI) network was constructed and analyzed on the String database, and then enrichment analysis was performed by the Metascape platform to determine the main Gene Ontology biological processes and Kyoto Encyclopedia of Genes and Genomes pathways. Finally, the Ingredient-Target-Pathway (I-T-P) network was constructed and analyzed by Cytoscape software. Results: Six active ingredients of P. lactiflora (kaempferol, ß-sitosterol, betulinic acid, palbinone, paeoniflorin and (+)-catechin) as well as six core targets strongly related to PD treatment [AKT1, interleukin-6, CAT, Tumor necrosis factor (TNF), CASP3, and PTGS2] were identified. The main pathways were shown to involve neuroactive ligand-receptor interaction, Calcium signaling pathway, PI3-Akt signaling pathway, TNF signaling pathway, and apoptosis signaling pathway. The main biological process included the regulation of neurotransmitter levels. Conclusion: P. lactiflora may retard neurodegeneration by reducing neuroinflammation, inhibiting intrinsic and extrinsic apoptosis, and may improve motor and non-motor symptoms by regulating the levels of neurotransmitters. Our study has revealed the mechanism of P. lactiflora in the treatment of PD and may contribute to novel drug development for PD. Frontiers Media S.A. 2020-11-23 /pmc/articles/PMC7768820/ /pubmed/33381034 http://dx.doi.org/10.3389/fphar.2020.581984 Text en Copyright © 2020 Du, Liang, Wang, Lee and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Du, Wanqing Liang, Xiao Wang, Shanze Lee, Philip Zhang, Yunling The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach |
title | The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach |
title_full | The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach |
title_fullStr | The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach |
title_full_unstemmed | The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach |
title_short | The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson’s Disease Based on a Network Pharmacology Approach |
title_sort | underlying mechanism of paeonia lactiflora pall. in parkinson’s disease based on a network pharmacology approach |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768820/ https://www.ncbi.nlm.nih.gov/pubmed/33381034 http://dx.doi.org/10.3389/fphar.2020.581984 |
work_keys_str_mv | AT duwanqing theunderlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT liangxiao theunderlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT wangshanze theunderlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT leephilip theunderlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT zhangyunling theunderlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT duwanqing underlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT liangxiao underlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT wangshanze underlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT leephilip underlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach AT zhangyunling underlyingmechanismofpaeonialactiflorapallinparkinsonsdiseasebasedonanetworkpharmacologyapproach |