Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis

Chronic inflammation is part of the pathological process during atherosclerosis (AS). Due to the abundance of monocytes/macrophages within the arterial plaque, monocytes/macrophages have become a critical cellular target in AS studies. In recent decades, a number of long noncoding RNAs (lncRNAs) hav...

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Detalles Bibliográficos
Autores principales: Ma, Xirui, Liu, Huifang, Chen, Fengling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768882/
https://www.ncbi.nlm.nih.gov/pubmed/33381026
http://dx.doi.org/10.3389/fphar.2020.567582
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author Ma, Xirui
Liu, Huifang
Chen, Fengling
author_facet Ma, Xirui
Liu, Huifang
Chen, Fengling
author_sort Ma, Xirui
collection PubMed
description Chronic inflammation is part of the pathological process during atherosclerosis (AS). Due to the abundance of monocytes/macrophages within the arterial plaque, monocytes/macrophages have become a critical cellular target in AS studies. In recent decades, a number of long noncoding RNAs (lncRNAs) have been found to exert regulatory roles on the macrophage metabolism and macrophage plasticity, consequently promoting or suppressing atherosclerotic inflammation. In this review, we provide a comprehensive overview of lncRNAs in macrophage biology, highlighting the potential role of lncRNAs in AS based on recent findings, with the aim to identify disease biomarkers and future therapeutic interventions for AS.
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spelling pubmed-77688822020-12-29 Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis Ma, Xirui Liu, Huifang Chen, Fengling Front Pharmacol Pharmacology Chronic inflammation is part of the pathological process during atherosclerosis (AS). Due to the abundance of monocytes/macrophages within the arterial plaque, monocytes/macrophages have become a critical cellular target in AS studies. In recent decades, a number of long noncoding RNAs (lncRNAs) have been found to exert regulatory roles on the macrophage metabolism and macrophage plasticity, consequently promoting or suppressing atherosclerotic inflammation. In this review, we provide a comprehensive overview of lncRNAs in macrophage biology, highlighting the potential role of lncRNAs in AS based on recent findings, with the aim to identify disease biomarkers and future therapeutic interventions for AS. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7768882/ /pubmed/33381026 http://dx.doi.org/10.3389/fphar.2020.567582 Text en Copyright © 2020 Ma, Liu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ma, Xirui
Liu, Huifang
Chen, Fengling
Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis
title Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis
title_full Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis
title_fullStr Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis
title_full_unstemmed Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis
title_short Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis
title_sort functioning of long noncoding rnas expressed in macrophage in the development of atherosclerosis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768882/
https://www.ncbi.nlm.nih.gov/pubmed/33381026
http://dx.doi.org/10.3389/fphar.2020.567582
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