Cargando…

Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent

B-cell lymphoma 2 (BCL-2) family proteins primarily work as a programmed cell death regulator, whereby multiple interactions between them determine cell survival. This explains the two major classes of BCL-2 proteins which are anti-apoptotic and pro-apoptotic proteins. The anti-apoptotic proteins ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohamad Anuar, Nur Najmi, Nor Hisam, Nur Syahidah, Liew, Sze Ling, Ugusman, Azizah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768911/ https://www.ncbi.nlm.nih.gov/pubmed/33381025 http://dx.doi.org/10.3389/fphar.2020.564108

Ejemplares similares

Combination Therapy of Navitoclax with Chemotherapeutic Agents in Solid Tumors and Blood Cancer: A Review of Current Evidence
por: Nor Hisam, Nur Syahidah, et al.
Publicado: (2021)

Evaluating the Potential of Plukenetia volubilis Linneo (Sacha Inchi) in Alleviating Cardiovascular Disease Risk Factors: A Mini Review
por: Abd Rahman, Izzat Zulhilmi, et al.
Publicado: (2023)

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
por: Zhu, Yi, et al.
Publicado: (2016)

Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies
por: Rami, Afifah Zahirah Abd, et al.
Publicado: (2022)

Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis
por: Othman, Nur Syakirah, et al.
Publicado: (2022)

Persicaria minor (Huds.) Opiz Prevents In Vitro Atherogenesis by Attenuating Tumor Necrosis Factor-α-Induced Monocyte Adhesion to Human Umbilical Vein Endothelial Cells
por: Hamid, Adila A., et al.
Publicado: (2022)

The Anti-Viral and Anti-Inflammatory Properties of Edible Bird’s Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical Application
por: Chua, Kien Hui, et al.
Publicado: (2021)

Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step
por: Weiskirchen, Ralf
Publicado: (2016)

Novel Anti-fibrotic Therapies
por: McVicker, Benita L., et al.
Publicado: (2017)

The Role of Navitoclax in Myelofibrosis
por: Pandravada, Sasirekha, et al.
Publicado: (2021)

Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia
por: Johansson, Kimberly B., et al.
Publicado: (2023)

Anti-fibrotic Potential of AT(2) Receptor Agonists
por: Wang, Yan, et al.
Publicado: (2017)

In Vitro Pro-apoptotic and Anti-migratory Effects of Ficus deltoidea L. Plant Extracts on the Human Prostate Cancer Cell Lines PC3
por: Hanafi, Mohd M. M., et al.
Publicado: (2017)

Piper sarmentosum Promotes Endothelial Nitric Oxide Production by Reducing Asymmetric Dimethylarginine in Tumor Necrosis Factor-α-Induced Human Umbilical Vein Endothelial Cells
por: Sundar, Uma Mahgesswary, et al.
Publicado: (2019)

Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis
por: Feng, Yunhui, et al.
Publicado: (2021)

A Clinical Perspective of Anti-Fibrotic Therapies for Cardiovascular Disease
por: Fang, Lu, et al.
Publicado: (2017)

15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo
por: Cai, Yihong, et al.
Publicado: (2018)

Nucleic Acids Delivery Into the Cells Using Pro-Apoptotic Protein Lactaptin
por: Chinak, Olga, et al.
Publicado: (2019)

Ganoderma Lucidum Polysaccharides Enhance the Abscopal Effect of Photothermal Therapy in Hepatoma-Bearing Mice Through Immunomodulatory, Anti-Proliferative, Pro-Apoptotic and Anti-Angiogenic
por: Xia, Qing-Hai, et al.
Publicado: (2021)

Editorial: Natural products for neuroprotection and neuroregeneration
por: Wong, Kah Hui, et al.
Publicado: (2023)

Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins
por: Yamamoto, Masahiro, et al.
Publicado: (2022)

Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury
por: Li, Xi, et al.
Publicado: (2023)

The Interaction Between Pulmonary Fibrosis and COVID-19 and the Application of Related Anti-Fibrotic Drugs
por: Shen, Hao, et al.
Publicado: (2022)

Organotin (IV) Dithiocarbamate Compounds as Anticancer Agents: A Review of Syntheses and Cytotoxicity Studies
por: Abd Aziz, Nurul Amalina, et al.
Publicado: (2023)

The Discovery of Novel PGK1 Activators as Apoptotic Inhibiting and Neuroprotective Agents
por: Qiang, Shao-Jia, et al.
Publicado: (2022)

Piper sarmentosum Roxb. Attenuates Vascular Endothelial Dysfunction in Nicotine-Induced Rats
por: Md. Salleh, Muhd Fakh Rur Razi, et al.
Publicado: (2021)

In Vivo Activation and Pro-Fibrotic Function of NF-κB in Fibroblastic Cells During Pulmonary Inflammation and Fibrosis Induced by Carbon Nanotubes
por: Dong, Jie, et al.
Publicado: (2019)

Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
por: Yang, Chunjing, et al.
Publicado: (2020)

Smoking and Unstable Plaque in Acute Coronary Syndrome: A Systematic Review of The Role of Matrix Metalloproteinases
por: Aminuddin, Amilia, et al.
Publicado: (2023)

Are mast cells instrumental for fibrotic diseases?
por: Overed-Sayer, Catherine, et al.
Publicado: (2014)

Pro-fibrotic SNPs
por: Maxmen, Amy
Publicado: (2009)

Anti-Apoptotic Role of Sanhuang Xiexin Decoction and Anisodamine in Endotoxemia
por: Liu, Zixuan, et al.
Publicado: (2021)

Clearance of systemic hematologic tumors by venetoclax (Abt-199) and navitoclax
por: Ackler, Scott, et al.
Publicado: (2015)

Sepsis: pro-apoptotic and anti-apoptotic signals in liver cells
por: Chatzigianni, EV, et al.
Publicado: (2002)

The pro-fibrotic and anti-inflammatory foam cell macrophage paradox
por: Thomas, Anita C., et al.
Publicado: (2015)

The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders
por: Mohd Nor, Nor Anizah, et al.
Publicado: (2022)

A subcritical water extract of soil grown Zingiber officinale Roscoe: Comparative analysis of antioxidant and anti-inflammatory effects and evaluation of bioactive metabolites
por: Razak, Azraul Mumtazah, et al.
Publicado: (2023)

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1
por: Pinar, Anita A., et al.
Publicado: (2020)

Anti-Fibrotic Effects of Low Toxic Microcystin-RR on Bleomycin-Induced Pulmonary Fibrosis: A Comparison with Microcystin-LR
por: Wang, Jie, et al.
Publicado: (2021)

Anti-apoptotic and anti-fibrotic efficacy of exercise training in hypertensive hearts: A systematic review
por: Akbar, Adjar Yusrandi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_03fbkftfdti8v71p0k7vm59mpl