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What Can We Learn about Aging and COVID-19 by Studying Mortality?
Promising ideas and directions for further research into biology of aging are discussed using analysis of the age-related kinetics of organisms’ mortality. It is shown that the traditional evolutionary theory explaining aging by decreasing force of natural selection with age is not consistent with t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pleiades Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768994/ https://www.ncbi.nlm.nih.gov/pubmed/33705289 http://dx.doi.org/10.1134/S0006297920120032 |
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author | Gavrilov, L. A. Gavrilova, N. S. |
author_facet | Gavrilov, L. A. Gavrilova, N. S. |
author_sort | Gavrilov, L. A. |
collection | PubMed |
description | Promising ideas and directions for further research into biology of aging are discussed using analysis of the age-related kinetics of organisms’ mortality. It is shown that the traditional evolutionary theory explaining aging by decreasing force of natural selection with age is not consistent with the data on age-related mortality kinetics. The hypothesis of multistage destruction of organisms with age, including the rate-limiting stage of transition to a state of non-specific vulnerability (“non-survivor”), is discussed. It is found that the effect of the COVID-19 coronavirus infection on mortality is not additive (as it was the case with the Spanish flu epidemic in 1918), but multiplicative (proportional) for ages over 65 years. |
format | Online Article Text |
id | pubmed-7768994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Pleiades Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-77689942020-12-28 What Can We Learn about Aging and COVID-19 by Studying Mortality? Gavrilov, L. A. Gavrilova, N. S. Biochemistry (Mosc) Mini-Review Promising ideas and directions for further research into biology of aging are discussed using analysis of the age-related kinetics of organisms’ mortality. It is shown that the traditional evolutionary theory explaining aging by decreasing force of natural selection with age is not consistent with the data on age-related mortality kinetics. The hypothesis of multistage destruction of organisms with age, including the rate-limiting stage of transition to a state of non-specific vulnerability (“non-survivor”), is discussed. It is found that the effect of the COVID-19 coronavirus infection on mortality is not additive (as it was the case with the Spanish flu epidemic in 1918), but multiplicative (proportional) for ages over 65 years. Pleiades Publishing 2020-12-28 2020 /pmc/articles/PMC7768994/ /pubmed/33705289 http://dx.doi.org/10.1134/S0006297920120032 Text en © Pleiades Publishing, Ltd. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Mini-Review Gavrilov, L. A. Gavrilova, N. S. What Can We Learn about Aging and COVID-19 by Studying Mortality? |
title | What Can We Learn about Aging and COVID-19 by Studying Mortality? |
title_full | What Can We Learn about Aging and COVID-19 by Studying Mortality? |
title_fullStr | What Can We Learn about Aging and COVID-19 by Studying Mortality? |
title_full_unstemmed | What Can We Learn about Aging and COVID-19 by Studying Mortality? |
title_short | What Can We Learn about Aging and COVID-19 by Studying Mortality? |
title_sort | what can we learn about aging and covid-19 by studying mortality? |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768994/ https://www.ncbi.nlm.nih.gov/pubmed/33705289 http://dx.doi.org/10.1134/S0006297920120032 |
work_keys_str_mv | AT gavrilovla whatcanwelearnaboutagingandcovid19bystudyingmortality AT gavrilovans whatcanwelearnaboutagingandcovid19bystudyingmortality |