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Metabolic ROS Signaling: To Immunity and Beyond
Metabolism is a critical determinant of immune cell functionality. Immunometabolism, by definition, is a multidisciplinary area of immunology research that integrates the knowledge of energy transduction mechanisms and biochemical pathways. An important concept in the field is metabolic switch, a tr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pleiades Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768995/ https://www.ncbi.nlm.nih.gov/pubmed/33705302 http://dx.doi.org/10.1134/S0006297920120160 |
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author | Andreyev, A. Y. Kushnareva, Y. E. Starkova, N. N. Starkov, A. A. |
author_facet | Andreyev, A. Y. Kushnareva, Y. E. Starkova, N. N. Starkov, A. A. |
author_sort | Andreyev, A. Y. |
collection | PubMed |
description | Metabolism is a critical determinant of immune cell functionality. Immunometabolism, by definition, is a multidisciplinary area of immunology research that integrates the knowledge of energy transduction mechanisms and biochemical pathways. An important concept in the field is metabolic switch, a transition of immune cells upon activation to preferential utilization of select catabolic pathways for their energy needs. Mitochondria are not inert in this process and contribute to the metabolic adaptation by different mechanisms which include increasing ATP production to match dynamic bioenergetic demands and serving as a signaling platform. The latter involves generation of reactive oxygen species (ROS), one of the most intensively studied mitochondrial processes. While the role of mitochondrial ROS in the context of oxidative stress is well established, ROS signaling in immunity is an emerging and quickly changing field. In this review, we discuss ROS signaling and immunometabolism concepts from the standpoint of bioenergetics. We also provide a critical insight into the methodology for ROS assessment, outlining current challenges in the field. Finally, based on our analysis of the literature data, we hypothesize that regulatory ROS production, as opposed to oxidative stress, is controlled by mitochondrial biogenesis rather than metabolic switches. |
format | Online Article Text |
id | pubmed-7768995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Pleiades Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-77689952020-12-28 Metabolic ROS Signaling: To Immunity and Beyond Andreyev, A. Y. Kushnareva, Y. E. Starkova, N. N. Starkov, A. A. Biochemistry (Mosc) Review Metabolism is a critical determinant of immune cell functionality. Immunometabolism, by definition, is a multidisciplinary area of immunology research that integrates the knowledge of energy transduction mechanisms and biochemical pathways. An important concept in the field is metabolic switch, a transition of immune cells upon activation to preferential utilization of select catabolic pathways for their energy needs. Mitochondria are not inert in this process and contribute to the metabolic adaptation by different mechanisms which include increasing ATP production to match dynamic bioenergetic demands and serving as a signaling platform. The latter involves generation of reactive oxygen species (ROS), one of the most intensively studied mitochondrial processes. While the role of mitochondrial ROS in the context of oxidative stress is well established, ROS signaling in immunity is an emerging and quickly changing field. In this review, we discuss ROS signaling and immunometabolism concepts from the standpoint of bioenergetics. We also provide a critical insight into the methodology for ROS assessment, outlining current challenges in the field. Finally, based on our analysis of the literature data, we hypothesize that regulatory ROS production, as opposed to oxidative stress, is controlled by mitochondrial biogenesis rather than metabolic switches. Pleiades Publishing 2020-12-28 2020 /pmc/articles/PMC7768995/ /pubmed/33705302 http://dx.doi.org/10.1134/S0006297920120160 Text en © Pleiades Publishing, Ltd. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Andreyev, A. Y. Kushnareva, Y. E. Starkova, N. N. Starkov, A. A. Metabolic ROS Signaling: To Immunity and Beyond |
title | Metabolic ROS Signaling: To Immunity and Beyond |
title_full | Metabolic ROS Signaling: To Immunity and Beyond |
title_fullStr | Metabolic ROS Signaling: To Immunity and Beyond |
title_full_unstemmed | Metabolic ROS Signaling: To Immunity and Beyond |
title_short | Metabolic ROS Signaling: To Immunity and Beyond |
title_sort | metabolic ros signaling: to immunity and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768995/ https://www.ncbi.nlm.nih.gov/pubmed/33705302 http://dx.doi.org/10.1134/S0006297920120160 |
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