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Antibiotics from Extremophilic Micromycetes
Extremophilic microorganisms, which are capable of functioning normally at extremely high or low temperatures, pressure, and in other environmental conditions, have been in the focus of microbiologists’ attention for several decades due to the biotechnological potential of enzymes inherent in extrem...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pleiades Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768999/ https://www.ncbi.nlm.nih.gov/pubmed/33390684 http://dx.doi.org/10.1134/S1068162020060023 |
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author | Baranova, A. A. Alferova, V. A. Korshun, V. A. Tyurin, A. P. |
author_facet | Baranova, A. A. Alferova, V. A. Korshun, V. A. Tyurin, A. P. |
author_sort | Baranova, A. A. |
collection | PubMed |
description | Extremophilic microorganisms, which are capable of functioning normally at extremely high or low temperatures, pressure, and in other environmental conditions, have been in the focus of microbiologists’ attention for several decades due to the biotechnological potential of enzymes inherent in extremophiles. These enzymes (also called extremozymes) are used in the production of food and detergents and other industries. At the same time, the inhabitants of extreme econiches remained almost unexplored for a long time in terms of the chemistry of natural compounds. In recent years, the emergence of new antibiotic-resistant strains of pathogens, which affect humans and animals has become a global problem. The problem is compounded by a strong slowdown in the development of new antibiotics. In search of new active substances and scaffolds for medical chemistry, researchers turn to unexplored natural sources. In recent years, there has been a sharp increase in the number of studies on secondary metabolites produced by extremophiles. From the discovery of penicillin to the present day, micromycetes, along with actinobacteria, are one of the most productive sources of antibiotic compounds for medicine and agriculture. Many authors consider extremophilic micromycetes as a promising source of small molecules with an unusual mechanism of action or significant structural novelty. This review summarizes the latest (for 2018–2019) experimental data on antibiotic compounds, which are produced by extremophilic micromycetes with various types of adaptation. Active metabolites are classified by the type of structure and biosynthetic origin. The data on the biological activity of the isolated metabolites are summarized. |
format | Online Article Text |
id | pubmed-7768999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Pleiades Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-77689992020-12-28 Antibiotics from Extremophilic Micromycetes Baranova, A. A. Alferova, V. A. Korshun, V. A. Tyurin, A. P. Russ J Bioorg Chem Review Article Extremophilic microorganisms, which are capable of functioning normally at extremely high or low temperatures, pressure, and in other environmental conditions, have been in the focus of microbiologists’ attention for several decades due to the biotechnological potential of enzymes inherent in extremophiles. These enzymes (also called extremozymes) are used in the production of food and detergents and other industries. At the same time, the inhabitants of extreme econiches remained almost unexplored for a long time in terms of the chemistry of natural compounds. In recent years, the emergence of new antibiotic-resistant strains of pathogens, which affect humans and animals has become a global problem. The problem is compounded by a strong slowdown in the development of new antibiotics. In search of new active substances and scaffolds for medical chemistry, researchers turn to unexplored natural sources. In recent years, there has been a sharp increase in the number of studies on secondary metabolites produced by extremophiles. From the discovery of penicillin to the present day, micromycetes, along with actinobacteria, are one of the most productive sources of antibiotic compounds for medicine and agriculture. Many authors consider extremophilic micromycetes as a promising source of small molecules with an unusual mechanism of action or significant structural novelty. This review summarizes the latest (for 2018–2019) experimental data on antibiotic compounds, which are produced by extremophilic micromycetes with various types of adaptation. Active metabolites are classified by the type of structure and biosynthetic origin. The data on the biological activity of the isolated metabolites are summarized. Pleiades Publishing 2020-12-28 2020 /pmc/articles/PMC7768999/ /pubmed/33390684 http://dx.doi.org/10.1134/S1068162020060023 Text en © Pleiades Publishing, Ltd. 2020, ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2020, Vol. 46, No. 6, pp. 903–971. © Pleiades Publishing, Ltd., 2020.Russian Text © The Author(s), 2020, published in Bioorganicheskaya Khimiya, 2020, Vol. 46, No. 6, pp. 593–665. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Baranova, A. A. Alferova, V. A. Korshun, V. A. Tyurin, A. P. Antibiotics from Extremophilic Micromycetes |
title | Antibiotics from Extremophilic Micromycetes |
title_full | Antibiotics from Extremophilic Micromycetes |
title_fullStr | Antibiotics from Extremophilic Micromycetes |
title_full_unstemmed | Antibiotics from Extremophilic Micromycetes |
title_short | Antibiotics from Extremophilic Micromycetes |
title_sort | antibiotics from extremophilic micromycetes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768999/ https://www.ncbi.nlm.nih.gov/pubmed/33390684 http://dx.doi.org/10.1134/S1068162020060023 |
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