Activated microglia cause metabolic disruptions in developmental cortical interneuron that persist in schizophrenia-patient-derived interneurons

The mechanisms by which prenatal immune activation increase risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs), known to be affected in schizophrenia (SCZ) when matured, from induced pluripotent stem cells (iPSCs) from healthy controls (HC)...

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Detalles Bibliográficos
Autores principales: Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S, Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769122/
https://www.ncbi.nlm.nih.gov/pubmed/33097921
http://dx.doi.org/10.1038/s41593-020-00724-1

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