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Targeting BRD9 for Cancer Treatment: A New Strategy

Bromodomain-containing protein 9 (BRD9) is a newly identified subunit of the non-canonical barrier-to-autointegration factor (ncBAF) complex and a member of the bromodomain family IV. Studies have confirmed that BRD9 plays an oncogenic role in multiple cancer types, by regulating tumor cell growth....

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Detalles Bibliográficos
Autores principales: Zhu, Xiuzuo, Liao, Yi, Tang, Liling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769155/
https://www.ncbi.nlm.nih.gov/pubmed/33380808
http://dx.doi.org/10.2147/OTT.S286867
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author Zhu, Xiuzuo
Liao, Yi
Tang, Liling
author_facet Zhu, Xiuzuo
Liao, Yi
Tang, Liling
author_sort Zhu, Xiuzuo
collection PubMed
description Bromodomain-containing protein 9 (BRD9) is a newly identified subunit of the non-canonical barrier-to-autointegration factor (ncBAF) complex and a member of the bromodomain family IV. Studies have confirmed that BRD9 plays an oncogenic role in multiple cancer types, by regulating tumor cell growth. The tumor biological functions of BRD9 are mainly due to epigenetic modification mediated by its bromodomain. The bromodomain recruits the ncBAF complex to the promoter to regulate gene transcription. This review summarizes the potential mechanisms of action of BRD9 in carcinogenesis and the emerging strategies for targeting BRD9 for cancer therapeutics. Although the therapeutic potential of BRD9 has been exploited to some extent, research on the detailed biological mechanisms of BRD9 is still in its infancy. Therefore, targeting BRD9 to study its biological roles will be an attractive tool for cancer diagnosis and treatment, but it remains a great challenge.
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spelling pubmed-77691552020-12-29 Targeting BRD9 for Cancer Treatment: A New Strategy Zhu, Xiuzuo Liao, Yi Tang, Liling Onco Targets Ther Review Bromodomain-containing protein 9 (BRD9) is a newly identified subunit of the non-canonical barrier-to-autointegration factor (ncBAF) complex and a member of the bromodomain family IV. Studies have confirmed that BRD9 plays an oncogenic role in multiple cancer types, by regulating tumor cell growth. The tumor biological functions of BRD9 are mainly due to epigenetic modification mediated by its bromodomain. The bromodomain recruits the ncBAF complex to the promoter to regulate gene transcription. This review summarizes the potential mechanisms of action of BRD9 in carcinogenesis and the emerging strategies for targeting BRD9 for cancer therapeutics. Although the therapeutic potential of BRD9 has been exploited to some extent, research on the detailed biological mechanisms of BRD9 is still in its infancy. Therefore, targeting BRD9 to study its biological roles will be an attractive tool for cancer diagnosis and treatment, but it remains a great challenge. Dove 2020-12-24 /pmc/articles/PMC7769155/ /pubmed/33380808 http://dx.doi.org/10.2147/OTT.S286867 Text en © 2020 Zhu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhu, Xiuzuo
Liao, Yi
Tang, Liling
Targeting BRD9 for Cancer Treatment: A New Strategy
title Targeting BRD9 for Cancer Treatment: A New Strategy
title_full Targeting BRD9 for Cancer Treatment: A New Strategy
title_fullStr Targeting BRD9 for Cancer Treatment: A New Strategy
title_full_unstemmed Targeting BRD9 for Cancer Treatment: A New Strategy
title_short Targeting BRD9 for Cancer Treatment: A New Strategy
title_sort targeting brd9 for cancer treatment: a new strategy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769155/
https://www.ncbi.nlm.nih.gov/pubmed/33380808
http://dx.doi.org/10.2147/OTT.S286867
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