Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

Immunodominance to nonneutralizing epitopes is a roadblock in designing vaccines against several diseases of high interest. One hypothetical possibility is that limited CD4 T cell help to B cells in a normal germinal center (GC) response results in selective recruitment of abundant, immunodominant B...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jeong Hyun, Hu, Joyce K., Georgeson, Erik, Nakao, Catherine, Groschel, Bettina, Dileepan, Thamotharampillai, Jenkins, Marc K., Seumois, Gregory, Vijayanand, Pandurangan, Schief, William R., Crotty, Shane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769167/
https://www.ncbi.nlm.nih.gov/pubmed/33355623
http://dx.doi.org/10.1084/jem.20201254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769167/
https://www.ncbi.nlm.nih.gov/pubmed/33355623
http://dx.doi.org/10.1084/jem.20201254

Ejemplares similares