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Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis

BACKGROUND: Glioblastoma is an aggressive form of brain cancer with significant morbidity and mortality. This study aims to determine the radiotherapy for treatment of elderly people with diagnosed glioblastoma. METHOD: This study adheres to the Preferred Reporting Items for Systematic Reviews and M...

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Autores principales: Huang, Puxin, Li, Liqiang, Qiao, Juntang, Li, Xiang, Zhang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769296/
https://www.ncbi.nlm.nih.gov/pubmed/33350785
http://dx.doi.org/10.1097/MD.0000000000023890
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author Huang, Puxin
Li, Liqiang
Qiao, Juntang
Li, Xiang
Zhang, Peng
author_facet Huang, Puxin
Li, Liqiang
Qiao, Juntang
Li, Xiang
Zhang, Peng
author_sort Huang, Puxin
collection PubMed
description BACKGROUND: Glioblastoma is an aggressive form of brain cancer with significant morbidity and mortality. This study aims to determine the radiotherapy for treatment of elderly people with diagnosed glioblastoma. METHOD: This study adheres to the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols. Chinese electronic Database (CBM, Wanfang, and CNKI) and international electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) will be searched for all relevant published articles, with no restrictions on the year of publication or language. Study selection, data collection, and assessment of study bias will be conducted independently by a pair of independent reviewers. The Cochrane Risk of bias (ROB) tool will be used for the risk of bias assessment. The Grading of Recommendations Assessment Development and Evaluation (GRADE) system will be used to assess the quality of evidence. The statistical analysis of this meta-analysis will be calculated by Review manager version 5.3. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: The findings of this review will to provide high-level evidence in terms of the benefits and harms of radiotherapy in people with glioblastoma to provide meaningful conclusions for clinical practice and further research. TRIAL REGISTRATION: This study protocol was registered in open Science framework (OSF), (Registration DOI: 10.17605/OSF.IO/A6BCS).
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spelling pubmed-77692962020-12-29 Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis Huang, Puxin Li, Liqiang Qiao, Juntang Li, Xiang Zhang, Peng Medicine (Baltimore) 5300 BACKGROUND: Glioblastoma is an aggressive form of brain cancer with significant morbidity and mortality. This study aims to determine the radiotherapy for treatment of elderly people with diagnosed glioblastoma. METHOD: This study adheres to the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols. Chinese electronic Database (CBM, Wanfang, and CNKI) and international electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) will be searched for all relevant published articles, with no restrictions on the year of publication or language. Study selection, data collection, and assessment of study bias will be conducted independently by a pair of independent reviewers. The Cochrane Risk of bias (ROB) tool will be used for the risk of bias assessment. The Grading of Recommendations Assessment Development and Evaluation (GRADE) system will be used to assess the quality of evidence. The statistical analysis of this meta-analysis will be calculated by Review manager version 5.3. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: The findings of this review will to provide high-level evidence in terms of the benefits and harms of radiotherapy in people with glioblastoma to provide meaningful conclusions for clinical practice and further research. TRIAL REGISTRATION: This study protocol was registered in open Science framework (OSF), (Registration DOI: 10.17605/OSF.IO/A6BCS). Lippincott Williams & Wilkins 2020-12-24 /pmc/articles/PMC7769296/ /pubmed/33350785 http://dx.doi.org/10.1097/MD.0000000000023890 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5300
Huang, Puxin
Li, Liqiang
Qiao, Juntang
Li, Xiang
Zhang, Peng
Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis
title Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis
title_full Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis
title_fullStr Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis
title_full_unstemmed Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis
title_short Radiotherapy for glioblastoma in the elderly: A protocol for systematic review and meta-analysis
title_sort radiotherapy for glioblastoma in the elderly: a protocol for systematic review and meta-analysis
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769296/
https://www.ncbi.nlm.nih.gov/pubmed/33350785
http://dx.doi.org/10.1097/MD.0000000000023890
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