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Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam
PURPOSE: To generate a Cerenkov scatter function (CSF) for a primary proton beam and to study the dependence of the CSF on the irradiated medium. MATERIALS AND METHODS: The MCNP 6.2 code was used to generate the CSF. The CSF was calculated for light‐pigmented, medium‐pigmented, and dark‐pigmented st...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769394/ https://www.ncbi.nlm.nih.gov/pubmed/33124752 http://dx.doi.org/10.1002/acm2.13083 |
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author | Thompson, Steven A. |
author_facet | Thompson, Steven A. |
author_sort | Thompson, Steven A. |
collection | PubMed |
description | PURPOSE: To generate a Cerenkov scatter function (CSF) for a primary proton beam and to study the dependence of the CSF on the irradiated medium. MATERIALS AND METHODS: The MCNP 6.2 code was used to generate the CSF. The CSF was calculated for light‐pigmented, medium‐pigmented, and dark‐pigmented stratified skin, as well as for a homogeneous optical phantom, which mimics the optical properties of human tissue. CSFs were generated by binning all of the Cerenkov photons which escape the back end (end opposite beam incidence) of a 20 × 20 × 20 cm phantom. A 4 × 4 cm, 500 × 500 bin grid was used to create a histogram of the Cerenkov photon flux on the simulated medium’s back surface (surface opposite beam incidence). A triple Gaussian was then used to fit the data. RESULTS: From the triple Gaussian fit, the coefficients of the CSF for the four phantom materials was generated. The individual CSF fit coefficient errors, with respect to the Gaussian representation, were found to be between 0.92% and 4.11%. The R(2) value for the fit was calculated to be 0.99. The phantom material was found to have a significant effect (63% difference between materials) on the CSF amplitude and full width at half maximum (195% difference between materials). The difference in these parameters for the three skin pigments was found to be small. CONCLUSIONS: The CSF was obtained for a proton beam using the MCNP 6.2 code for a phantom constructed of light, medium, and dark stratified human skin, as well as for an optical phantom. The CSFs were then fit with a triple‐Gaussian function. The coefficients can be used to generate a radially symmetric CSF, which can then be used to deconvolve a measured Cerenkov image to obtain the dose distribution. |
format | Online Article Text |
id | pubmed-7769394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77693942020-12-31 Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam Thompson, Steven A. J Appl Clin Med Phys Technical Notes PURPOSE: To generate a Cerenkov scatter function (CSF) for a primary proton beam and to study the dependence of the CSF on the irradiated medium. MATERIALS AND METHODS: The MCNP 6.2 code was used to generate the CSF. The CSF was calculated for light‐pigmented, medium‐pigmented, and dark‐pigmented stratified skin, as well as for a homogeneous optical phantom, which mimics the optical properties of human tissue. CSFs were generated by binning all of the Cerenkov photons which escape the back end (end opposite beam incidence) of a 20 × 20 × 20 cm phantom. A 4 × 4 cm, 500 × 500 bin grid was used to create a histogram of the Cerenkov photon flux on the simulated medium’s back surface (surface opposite beam incidence). A triple Gaussian was then used to fit the data. RESULTS: From the triple Gaussian fit, the coefficients of the CSF for the four phantom materials was generated. The individual CSF fit coefficient errors, with respect to the Gaussian representation, were found to be between 0.92% and 4.11%. The R(2) value for the fit was calculated to be 0.99. The phantom material was found to have a significant effect (63% difference between materials) on the CSF amplitude and full width at half maximum (195% difference between materials). The difference in these parameters for the three skin pigments was found to be small. CONCLUSIONS: The CSF was obtained for a proton beam using the MCNP 6.2 code for a phantom constructed of light, medium, and dark stratified human skin, as well as for an optical phantom. The CSFs were then fit with a triple‐Gaussian function. The coefficients can be used to generate a radially symmetric CSF, which can then be used to deconvolve a measured Cerenkov image to obtain the dose distribution. John Wiley and Sons Inc. 2020-10-30 /pmc/articles/PMC7769394/ /pubmed/33124752 http://dx.doi.org/10.1002/acm2.13083 Text en © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Technical Notes Thompson, Steven A. Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam |
title | Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam |
title_full | Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam |
title_fullStr | Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam |
title_full_unstemmed | Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam |
title_short | Technical note: Generation of a Cerenkov scatter function convolution kernel for a primary proton beam |
title_sort | technical note: generation of a cerenkov scatter function convolution kernel for a primary proton beam |
topic | Technical Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769394/ https://www.ncbi.nlm.nih.gov/pubmed/33124752 http://dx.doi.org/10.1002/acm2.13083 |
work_keys_str_mv | AT thompsonstevena technicalnotegenerationofacerenkovscatterfunctionconvolutionkernelforaprimaryprotonbeam |