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Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study
BACKGROUND: Despite the prognostic importance of hypoalbuminemia, the prognostic implication of a change in albumin levels has not been fully investigated during hospitalization in patients with acute decompensated heart failure (ADHF). METHODS: Using the data from the Kyoto Congestive Heart Failure...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769473/ https://www.ncbi.nlm.nih.gov/pubmed/33370299 http://dx.doi.org/10.1371/journal.pone.0243818 |
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author | Kato, Takao Yaku, Hidenori Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Taniguchi, Ryoji Iguchi, Moritake Kato, Masashi Takahashi, Mamoru Jinnai, Toshikazu Ikeda, Tomoyuki Nagao, Kazuya Kawai, Takafumi Komasa, Akihiro Nishikawa, Ryusuke Kawase, Yuichi Morinaga, Takashi Kawato, Mitsunori Seko, Yuta Shiba, Masayuki Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi |
author_facet | Kato, Takao Yaku, Hidenori Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Taniguchi, Ryoji Iguchi, Moritake Kato, Masashi Takahashi, Mamoru Jinnai, Toshikazu Ikeda, Tomoyuki Nagao, Kazuya Kawai, Takafumi Komasa, Akihiro Nishikawa, Ryusuke Kawase, Yuichi Morinaga, Takashi Kawato, Mitsunori Seko, Yuta Shiba, Masayuki Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi |
author_sort | Kato, Takao |
collection | PubMed |
description | BACKGROUND: Despite the prognostic importance of hypoalbuminemia, the prognostic implication of a change in albumin levels has not been fully investigated during hospitalization in patients with acute decompensated heart failure (ADHF). METHODS: Using the data from the Kyoto Congestive Heart Failure registry on 3160 patients who were discharged alive for acute heart failure hospitalization and in whom the change in albumin levels was calculated at discharge, we evaluated the association with an increase in serum albumin levels from admission to discharge and clinical outcomes by a multivariable Cox hazard model. The primary outcome measure was a composite of all-cause death or hospitalization for heart failure. FINDINGS: Patients with increased albumin levels (N = 1083, 34.3%) were younger and less often had smaller body mass index and renal dysfunction than those with no increase in albumin levels (N = 2077, 65.7%). Median follow-up was 475 days with a 96% 1-year follow-up rate. Relative to the group with no increase in albumin levels, the lower risk of the increased albumin group remained significant for the primary outcome measure (hazard ratio: 0.78, 95% confidence interval: 0.69–0.90: P = 0.0004) after adjusting for confounders including baseline albumin levels. When stratified by the quartiles of baseline albumin levels, the favorable effect of increased albumin was more pronounced in the lower quartiles of albumin levels, but without a significant interaction effect (interaction P = 0.49). CONCLUSIONS: Independent of baseline albumin levels, an increase in albumin during index hospitalization was associated with a lower 1-year risk for a composite of all-cause death and hospitalization in patients with acute heart failure. |
format | Online Article Text |
id | pubmed-7769473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77694732021-01-08 Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study Kato, Takao Yaku, Hidenori Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Taniguchi, Ryoji Iguchi, Moritake Kato, Masashi Takahashi, Mamoru Jinnai, Toshikazu Ikeda, Tomoyuki Nagao, Kazuya Kawai, Takafumi Komasa, Akihiro Nishikawa, Ryusuke Kawase, Yuichi Morinaga, Takashi Kawato, Mitsunori Seko, Yuta Shiba, Masayuki Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi PLoS One Research Article BACKGROUND: Despite the prognostic importance of hypoalbuminemia, the prognostic implication of a change in albumin levels has not been fully investigated during hospitalization in patients with acute decompensated heart failure (ADHF). METHODS: Using the data from the Kyoto Congestive Heart Failure registry on 3160 patients who were discharged alive for acute heart failure hospitalization and in whom the change in albumin levels was calculated at discharge, we evaluated the association with an increase in serum albumin levels from admission to discharge and clinical outcomes by a multivariable Cox hazard model. The primary outcome measure was a composite of all-cause death or hospitalization for heart failure. FINDINGS: Patients with increased albumin levels (N = 1083, 34.3%) were younger and less often had smaller body mass index and renal dysfunction than those with no increase in albumin levels (N = 2077, 65.7%). Median follow-up was 475 days with a 96% 1-year follow-up rate. Relative to the group with no increase in albumin levels, the lower risk of the increased albumin group remained significant for the primary outcome measure (hazard ratio: 0.78, 95% confidence interval: 0.69–0.90: P = 0.0004) after adjusting for confounders including baseline albumin levels. When stratified by the quartiles of baseline albumin levels, the favorable effect of increased albumin was more pronounced in the lower quartiles of albumin levels, but without a significant interaction effect (interaction P = 0.49). CONCLUSIONS: Independent of baseline albumin levels, an increase in albumin during index hospitalization was associated with a lower 1-year risk for a composite of all-cause death and hospitalization in patients with acute heart failure. Public Library of Science 2020-12-28 /pmc/articles/PMC7769473/ /pubmed/33370299 http://dx.doi.org/10.1371/journal.pone.0243818 Text en © 2020 Kato et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kato, Takao Yaku, Hidenori Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Taniguchi, Ryoji Iguchi, Moritake Kato, Masashi Takahashi, Mamoru Jinnai, Toshikazu Ikeda, Tomoyuki Nagao, Kazuya Kawai, Takafumi Komasa, Akihiro Nishikawa, Ryusuke Kawase, Yuichi Morinaga, Takashi Kawato, Mitsunori Seko, Yuta Shiba, Masayuki Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study |
title | Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study |
title_full | Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study |
title_fullStr | Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study |
title_full_unstemmed | Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study |
title_short | Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study |
title_sort | association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: a cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769473/ https://www.ncbi.nlm.nih.gov/pubmed/33370299 http://dx.doi.org/10.1371/journal.pone.0243818 |
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