Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

BACKGROUND: The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). METHODS: Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. RESULTS: All...

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Detalles Bibliográficos
Autores principales: Dargelos, Mathilde, Couturier, Aymeric, Ferlicot, Sophie, Goujon, Jean-Michel, Roque-Afonso, Anne-Marie, Gault, Elyanne, Touchard, Guy, Ory, Cecile, Kaaki, Sihem, Vilaine, Eve, Essig, Marie, Massy, Ziad A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Exceptional Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769537/
https://www.ncbi.nlm.nih.gov/pubmed/33391755
http://dx.doi.org/10.1093/ckj/sfaa209
Descripción
Sumario:BACKGROUND: The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). METHODS: Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. RESULTS: All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. CONCLUSIONS: The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.

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