HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation

Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enhancers is still unclear. HOX TFs share conserved homeodomains...

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Detalles Bibliográficos
Autores principales: Bridoux, Laure, Zarrineh, Peyman, Mallen, Joshua, Phuycharoen, Mike, Latorre, Victor, Ladam, Frank, Losa, Marta, Baker, Syed Murtuza, Sagerstrom, Charles, Mace, Kimberly A., Rattray, Magnus, Bobola, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769617/
https://www.ncbi.nlm.nih.gov/pubmed/33315856
http://dx.doi.org/10.1371/journal.pgen.1009162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769617/
https://www.ncbi.nlm.nih.gov/pubmed/33315856
http://dx.doi.org/10.1371/journal.pgen.1009162

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