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Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2
Mesenchymal stem cells (MSCs), defined as plastic adherent cells with multipotent differentiation capacity in vitro, are an emerging and valuable tool to treat a plethora of diseases due to their therapeutic mechanisms such as their paracrine activity, mitochondrial and organelle transfer, and trans...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769649/ https://www.ncbi.nlm.nih.gov/pubmed/33414832 http://dx.doi.org/10.1155/2020/8892189 |
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author | Juárez-Navarro, Karen J. Padilla-Camberos, Eduardo Díaz, Néstor Fabián Miranda-Altamirano, Ariel Díaz-Martínez, N. Emmanuel |
author_facet | Juárez-Navarro, Karen J. Padilla-Camberos, Eduardo Díaz, Néstor Fabián Miranda-Altamirano, Ariel Díaz-Martínez, N. Emmanuel |
author_sort | Juárez-Navarro, Karen J. |
collection | PubMed |
description | Mesenchymal stem cells (MSCs), defined as plastic adherent cells with multipotent differentiation capacity in vitro, are an emerging and valuable tool to treat a plethora of diseases due to their therapeutic mechanisms such as their paracrine activity, mitochondrial and organelle transfer, and transfer of therapeutic molecules via exosomes. Nowadays, there are more than a thousand registered clinical trials related to MSC application around the world, highlighting MSC role on difficult-to-treat high-incidence diseases such as the current COVID-19, HIV infections, and autoimmune and metabolic diseases. Here, we summarize a general overview of MSCs and their therapeutic mechanisms; also, we discuss some of the novel clinical trial protocols and their results as well as a comparison between the number of registries, countries, and search portals. |
format | Online Article Text |
id | pubmed-7769649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-77696492021-01-06 Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 Juárez-Navarro, Karen J. Padilla-Camberos, Eduardo Díaz, Néstor Fabián Miranda-Altamirano, Ariel Díaz-Martínez, N. Emmanuel Stem Cells Int Review Article Mesenchymal stem cells (MSCs), defined as plastic adherent cells with multipotent differentiation capacity in vitro, are an emerging and valuable tool to treat a plethora of diseases due to their therapeutic mechanisms such as their paracrine activity, mitochondrial and organelle transfer, and transfer of therapeutic molecules via exosomes. Nowadays, there are more than a thousand registered clinical trials related to MSC application around the world, highlighting MSC role on difficult-to-treat high-incidence diseases such as the current COVID-19, HIV infections, and autoimmune and metabolic diseases. Here, we summarize a general overview of MSCs and their therapeutic mechanisms; also, we discuss some of the novel clinical trial protocols and their results as well as a comparison between the number of registries, countries, and search portals. Hindawi 2020-12-18 /pmc/articles/PMC7769649/ /pubmed/33414832 http://dx.doi.org/10.1155/2020/8892189 Text en Copyright © 2020 Karen J. Juárez-Navarro et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Juárez-Navarro, Karen J. Padilla-Camberos, Eduardo Díaz, Néstor Fabián Miranda-Altamirano, Ariel Díaz-Martínez, N. Emmanuel Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 |
title | Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 |
title_full | Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 |
title_fullStr | Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 |
title_full_unstemmed | Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 |
title_short | Human Mesenchymal Stem Cells: The Present Alternative for High-Incidence Diseases, Even SARS-Cov-2 |
title_sort | human mesenchymal stem cells: the present alternative for high-incidence diseases, even sars-cov-2 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769649/ https://www.ncbi.nlm.nih.gov/pubmed/33414832 http://dx.doi.org/10.1155/2020/8892189 |
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