Cargando…

MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2

Colorectal cancer (CRC) is a leading cause of cancer-related death around the world whose recurrence and metastasis rate is high. Due to the underlying unclear pathogenesis, it is hard so far to predict the tumorigenesis and prevent its recurrence. YAP/TAZ has been reported to be activated and funct...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xia, Wang, Ai-li, Liu, Yuan-yuan, Zhao, Chen-xi, Zhou, Xue, Liu, Hai-long, Lin, Mo-bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769676/
https://www.ncbi.nlm.nih.gov/pubmed/33414893
http://dx.doi.org/10.1155/2020/5316276
_version_ 1783629378713812992
author Chen, Xia
Wang, Ai-li
Liu, Yuan-yuan
Zhao, Chen-xi
Zhou, Xue
Liu, Hai-long
Lin, Mo-bin
author_facet Chen, Xia
Wang, Ai-li
Liu, Yuan-yuan
Zhao, Chen-xi
Zhou, Xue
Liu, Hai-long
Lin, Mo-bin
author_sort Chen, Xia
collection PubMed
description Colorectal cancer (CRC) is a leading cause of cancer-related death around the world whose recurrence and metastasis rate is high. Due to the underlying unclear pathogenesis, it is hard so far to predict the tumorigenesis and prevent its recurrence. YAP/TAZ has been reported to be activated and functioned as a potential oncogene in multiple cancer types and proved to be essential for the carcinogenesis of most solid tumors. In the present study, we found that YAP/TAZ was markedly upregulated in CRC tissues comparing with the adjacent noncancerous tissues due to the downregulation of LATS2, the main upstream regulator. We further identified miR-429 as a direct regulator of LATS2-YAP/TAZ activation, suggesting that the miR-429-LATS2-YAP/TAZ might be novel effective diagnostic axis and therapeutic targets for CRC.
format Online
Article
Text
id pubmed-7769676
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-77696762021-01-06 MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2 Chen, Xia Wang, Ai-li Liu, Yuan-yuan Zhao, Chen-xi Zhou, Xue Liu, Hai-long Lin, Mo-bin Oxid Med Cell Longev Research Article Colorectal cancer (CRC) is a leading cause of cancer-related death around the world whose recurrence and metastasis rate is high. Due to the underlying unclear pathogenesis, it is hard so far to predict the tumorigenesis and prevent its recurrence. YAP/TAZ has been reported to be activated and functioned as a potential oncogene in multiple cancer types and proved to be essential for the carcinogenesis of most solid tumors. In the present study, we found that YAP/TAZ was markedly upregulated in CRC tissues comparing with the adjacent noncancerous tissues due to the downregulation of LATS2, the main upstream regulator. We further identified miR-429 as a direct regulator of LATS2-YAP/TAZ activation, suggesting that the miR-429-LATS2-YAP/TAZ might be novel effective diagnostic axis and therapeutic targets for CRC. Hindawi 2020-12-19 /pmc/articles/PMC7769676/ /pubmed/33414893 http://dx.doi.org/10.1155/2020/5316276 Text en Copyright © 2020 Xia Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Xia
Wang, Ai-li
Liu, Yuan-yuan
Zhao, Chen-xi
Zhou, Xue
Liu, Hai-long
Lin, Mo-bin
MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
title MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
title_full MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
title_fullStr MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
title_full_unstemmed MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
title_short MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2
title_sort mir-429 involves in the pathogenesis of colorectal cancer via directly targeting lats2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769676/
https://www.ncbi.nlm.nih.gov/pubmed/33414893
http://dx.doi.org/10.1155/2020/5316276
work_keys_str_mv AT chenxia mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2
AT wangaili mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2
AT liuyuanyuan mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2
AT zhaochenxi mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2
AT zhouxue mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2
AT liuhailong mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2
AT linmobin mir429involvesinthepathogenesisofcolorectalcancerviadirectlytargetinglats2