Cargando…

Superspreading in early transmissions of COVID-19 in Indonesia

This paper presents a study of early epidemiological assessment of COVID-19 transmission dynamics in Indonesia. The aim is to quantify heterogeneity in the numbers of secondary infections. To this end, we estimate the basic reproduction number [Formula: see text] and the overdispersion parameter [Fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasan, Agus, Susanto, Hadi, Kasim, Muhammad Firmansyah, Nuraini, Nuning, Lestari, Bony, Triany, Dessy, Widyastuti, Widyastuti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769976/
https://www.ncbi.nlm.nih.gov/pubmed/33372191
http://dx.doi.org/10.1038/s41598-020-79352-5
_version_ 1783629431689969664
author Hasan, Agus
Susanto, Hadi
Kasim, Muhammad Firmansyah
Nuraini, Nuning
Lestari, Bony
Triany, Dessy
Widyastuti, Widyastuti
author_facet Hasan, Agus
Susanto, Hadi
Kasim, Muhammad Firmansyah
Nuraini, Nuning
Lestari, Bony
Triany, Dessy
Widyastuti, Widyastuti
author_sort Hasan, Agus
collection PubMed
description This paper presents a study of early epidemiological assessment of COVID-19 transmission dynamics in Indonesia. The aim is to quantify heterogeneity in the numbers of secondary infections. To this end, we estimate the basic reproduction number [Formula: see text] and the overdispersion parameter [Formula: see text] at two regions in Indonesia: Jakarta–Depok and Batam. The method to estimate [Formula: see text] is based on a sequential Bayesian method, while the parameter [Formula: see text] is estimated by fitting the secondary case data with a negative binomial distribution. Based on the first 1288 confirmed cases collected from both regions, we find a high degree of individual-level variation in the transmission. The basic reproduction number [Formula: see text] is estimated at 6.79 and 2.47, while the overdispersion parameter [Formula: see text] of a negative-binomial distribution is estimated at 0.06 and 0.2 for Jakarta–Depok and Batam, respectively. This suggests that superspreading events played a key role in the early stage of the outbreak, i.e., a small number of infected individuals are responsible for large numbers of COVID-19 transmission. This finding can be used to determine effective public measures, such as rapid isolation and identification, which are critical since delay of diagnosis is the most common cause of superspreading events.
format Online
Article
Text
id pubmed-7769976
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-77699762020-12-30 Superspreading in early transmissions of COVID-19 in Indonesia Hasan, Agus Susanto, Hadi Kasim, Muhammad Firmansyah Nuraini, Nuning Lestari, Bony Triany, Dessy Widyastuti, Widyastuti Sci Rep Article This paper presents a study of early epidemiological assessment of COVID-19 transmission dynamics in Indonesia. The aim is to quantify heterogeneity in the numbers of secondary infections. To this end, we estimate the basic reproduction number [Formula: see text] and the overdispersion parameter [Formula: see text] at two regions in Indonesia: Jakarta–Depok and Batam. The method to estimate [Formula: see text] is based on a sequential Bayesian method, while the parameter [Formula: see text] is estimated by fitting the secondary case data with a negative binomial distribution. Based on the first 1288 confirmed cases collected from both regions, we find a high degree of individual-level variation in the transmission. The basic reproduction number [Formula: see text] is estimated at 6.79 and 2.47, while the overdispersion parameter [Formula: see text] of a negative-binomial distribution is estimated at 0.06 and 0.2 for Jakarta–Depok and Batam, respectively. This suggests that superspreading events played a key role in the early stage of the outbreak, i.e., a small number of infected individuals are responsible for large numbers of COVID-19 transmission. This finding can be used to determine effective public measures, such as rapid isolation and identification, which are critical since delay of diagnosis is the most common cause of superspreading events. Nature Publishing Group UK 2020-12-28 /pmc/articles/PMC7769976/ /pubmed/33372191 http://dx.doi.org/10.1038/s41598-020-79352-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hasan, Agus
Susanto, Hadi
Kasim, Muhammad Firmansyah
Nuraini, Nuning
Lestari, Bony
Triany, Dessy
Widyastuti, Widyastuti
Superspreading in early transmissions of COVID-19 in Indonesia
title Superspreading in early transmissions of COVID-19 in Indonesia
title_full Superspreading in early transmissions of COVID-19 in Indonesia
title_fullStr Superspreading in early transmissions of COVID-19 in Indonesia
title_full_unstemmed Superspreading in early transmissions of COVID-19 in Indonesia
title_short Superspreading in early transmissions of COVID-19 in Indonesia
title_sort superspreading in early transmissions of covid-19 in indonesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769976/
https://www.ncbi.nlm.nih.gov/pubmed/33372191
http://dx.doi.org/10.1038/s41598-020-79352-5
work_keys_str_mv AT hasanagus superspreadinginearlytransmissionsofcovid19inindonesia
AT susantohadi superspreadinginearlytransmissionsofcovid19inindonesia
AT kasimmuhammadfirmansyah superspreadinginearlytransmissionsofcovid19inindonesia
AT nuraininuning superspreadinginearlytransmissionsofcovid19inindonesia
AT lestaribony superspreadinginearlytransmissionsofcovid19inindonesia
AT trianydessy superspreadinginearlytransmissionsofcovid19inindonesia
AT widyastutiwidyastuti superspreadinginearlytransmissionsofcovid19inindonesia