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Superspreading in early transmissions of COVID-19 in Indonesia
This paper presents a study of early epidemiological assessment of COVID-19 transmission dynamics in Indonesia. The aim is to quantify heterogeneity in the numbers of secondary infections. To this end, we estimate the basic reproduction number [Formula: see text] and the overdispersion parameter [Fo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769976/ https://www.ncbi.nlm.nih.gov/pubmed/33372191 http://dx.doi.org/10.1038/s41598-020-79352-5 |
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author | Hasan, Agus Susanto, Hadi Kasim, Muhammad Firmansyah Nuraini, Nuning Lestari, Bony Triany, Dessy Widyastuti, Widyastuti |
author_facet | Hasan, Agus Susanto, Hadi Kasim, Muhammad Firmansyah Nuraini, Nuning Lestari, Bony Triany, Dessy Widyastuti, Widyastuti |
author_sort | Hasan, Agus |
collection | PubMed |
description | This paper presents a study of early epidemiological assessment of COVID-19 transmission dynamics in Indonesia. The aim is to quantify heterogeneity in the numbers of secondary infections. To this end, we estimate the basic reproduction number [Formula: see text] and the overdispersion parameter [Formula: see text] at two regions in Indonesia: Jakarta–Depok and Batam. The method to estimate [Formula: see text] is based on a sequential Bayesian method, while the parameter [Formula: see text] is estimated by fitting the secondary case data with a negative binomial distribution. Based on the first 1288 confirmed cases collected from both regions, we find a high degree of individual-level variation in the transmission. The basic reproduction number [Formula: see text] is estimated at 6.79 and 2.47, while the overdispersion parameter [Formula: see text] of a negative-binomial distribution is estimated at 0.06 and 0.2 for Jakarta–Depok and Batam, respectively. This suggests that superspreading events played a key role in the early stage of the outbreak, i.e., a small number of infected individuals are responsible for large numbers of COVID-19 transmission. This finding can be used to determine effective public measures, such as rapid isolation and identification, which are critical since delay of diagnosis is the most common cause of superspreading events. |
format | Online Article Text |
id | pubmed-7769976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77699762020-12-30 Superspreading in early transmissions of COVID-19 in Indonesia Hasan, Agus Susanto, Hadi Kasim, Muhammad Firmansyah Nuraini, Nuning Lestari, Bony Triany, Dessy Widyastuti, Widyastuti Sci Rep Article This paper presents a study of early epidemiological assessment of COVID-19 transmission dynamics in Indonesia. The aim is to quantify heterogeneity in the numbers of secondary infections. To this end, we estimate the basic reproduction number [Formula: see text] and the overdispersion parameter [Formula: see text] at two regions in Indonesia: Jakarta–Depok and Batam. The method to estimate [Formula: see text] is based on a sequential Bayesian method, while the parameter [Formula: see text] is estimated by fitting the secondary case data with a negative binomial distribution. Based on the first 1288 confirmed cases collected from both regions, we find a high degree of individual-level variation in the transmission. The basic reproduction number [Formula: see text] is estimated at 6.79 and 2.47, while the overdispersion parameter [Formula: see text] of a negative-binomial distribution is estimated at 0.06 and 0.2 for Jakarta–Depok and Batam, respectively. This suggests that superspreading events played a key role in the early stage of the outbreak, i.e., a small number of infected individuals are responsible for large numbers of COVID-19 transmission. This finding can be used to determine effective public measures, such as rapid isolation and identification, which are critical since delay of diagnosis is the most common cause of superspreading events. Nature Publishing Group UK 2020-12-28 /pmc/articles/PMC7769976/ /pubmed/33372191 http://dx.doi.org/10.1038/s41598-020-79352-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hasan, Agus Susanto, Hadi Kasim, Muhammad Firmansyah Nuraini, Nuning Lestari, Bony Triany, Dessy Widyastuti, Widyastuti Superspreading in early transmissions of COVID-19 in Indonesia |
title | Superspreading in early transmissions of COVID-19 in Indonesia |
title_full | Superspreading in early transmissions of COVID-19 in Indonesia |
title_fullStr | Superspreading in early transmissions of COVID-19 in Indonesia |
title_full_unstemmed | Superspreading in early transmissions of COVID-19 in Indonesia |
title_short | Superspreading in early transmissions of COVID-19 in Indonesia |
title_sort | superspreading in early transmissions of covid-19 in indonesia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769976/ https://www.ncbi.nlm.nih.gov/pubmed/33372191 http://dx.doi.org/10.1038/s41598-020-79352-5 |
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