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Glycosylation of Ca(V)3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes
Our previous studies implicated glycosylation of the Ca(V)3.2 isoform of T-type Ca(2+) channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms underlying the modulation of recombinant Ca(V)3.2 channel by de-glycosyl...
Autores principales: | Joksimovic, Sonja Lj., Evans, J. Grayson, McIntire, William E., Orestes, Peihan, Barrett, Paula Q., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770106/ https://www.ncbi.nlm.nih.gov/pubmed/33384586 http://dx.doi.org/10.3389/fncel.2020.605312 |
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