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Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression

Colorectal cancer (CRC) remains a devastating human malignancy with poor prognosis. Of the various factors, immune evasion mechanisms play pivotal roles in CRC progression and impede the effects of cancer therapy. Myeloid-derived suppressor cells (MDSCs) constitute an immature population of myeloid...

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Autores principales: Yin, Kai, Xia, Xueli, Rui, Ke, Wang, Tingting, Wang, Shengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770157/
https://www.ncbi.nlm.nih.gov/pubmed/33384962
http://dx.doi.org/10.3389/fonc.2020.610104
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author Yin, Kai
Xia, Xueli
Rui, Ke
Wang, Tingting
Wang, Shengjun
author_facet Yin, Kai
Xia, Xueli
Rui, Ke
Wang, Tingting
Wang, Shengjun
author_sort Yin, Kai
collection PubMed
description Colorectal cancer (CRC) remains a devastating human malignancy with poor prognosis. Of the various factors, immune evasion mechanisms play pivotal roles in CRC progression and impede the effects of cancer therapy. Myeloid-derived suppressor cells (MDSCs) constitute an immature population of myeloid cells that are typical during tumor progression. These cells have the ability to induce strong immunosuppressive effects within the tumor microenvironment (TME) and promote CRC development. Indeed, MDSCs have been shown to accumulate in both tumor-bearing mice and CRC patients, and may therefore become an obstacle for cancer immunotherapy. Consequently, numerous studies have focused on the characterization of MDSCs and their immunosuppressive capacity, as well as developing novel approaches to suppress MDSCs function with different approaches. Current therapeutic strategies that target MDSCs in CRC include inhibition of their recruitment and alteration of their function, alone or in combination with other therapies including chemotherapy, radiotherapy and immunotherapy. Herein, we summarize the recent roles and mechanisms of MDSCs in CRC progression. In addition, a brief review of MDSC-targeting approaches for potential CRC therapy is presented.
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spelling pubmed-77701572020-12-30 Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression Yin, Kai Xia, Xueli Rui, Ke Wang, Tingting Wang, Shengjun Front Oncol Oncology Colorectal cancer (CRC) remains a devastating human malignancy with poor prognosis. Of the various factors, immune evasion mechanisms play pivotal roles in CRC progression and impede the effects of cancer therapy. Myeloid-derived suppressor cells (MDSCs) constitute an immature population of myeloid cells that are typical during tumor progression. These cells have the ability to induce strong immunosuppressive effects within the tumor microenvironment (TME) and promote CRC development. Indeed, MDSCs have been shown to accumulate in both tumor-bearing mice and CRC patients, and may therefore become an obstacle for cancer immunotherapy. Consequently, numerous studies have focused on the characterization of MDSCs and their immunosuppressive capacity, as well as developing novel approaches to suppress MDSCs function with different approaches. Current therapeutic strategies that target MDSCs in CRC include inhibition of their recruitment and alteration of their function, alone or in combination with other therapies including chemotherapy, radiotherapy and immunotherapy. Herein, we summarize the recent roles and mechanisms of MDSCs in CRC progression. In addition, a brief review of MDSC-targeting approaches for potential CRC therapy is presented. Frontiers Media S.A. 2020-12-15 /pmc/articles/PMC7770157/ /pubmed/33384962 http://dx.doi.org/10.3389/fonc.2020.610104 Text en Copyright © 2020 Yin, Xia, Rui, Wang and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yin, Kai
Xia, Xueli
Rui, Ke
Wang, Tingting
Wang, Shengjun
Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
title Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
title_full Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
title_fullStr Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
title_full_unstemmed Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
title_short Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
title_sort myeloid-derived suppressor cells: a new and pivotal player in colorectal cancer progression
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770157/
https://www.ncbi.nlm.nih.gov/pubmed/33384962
http://dx.doi.org/10.3389/fonc.2020.610104
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