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Advanced glycation end products cause RAGE‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in vivo and in organ culture models

Aging and diabetes are associated with increased low‐back pain and intervertebral disk (IVD) degeneration yet causal mechanisms remain uncertain. Advanced glycation end products (AGEs), which accumulate in IVDs from aging and are implicated in diabetes‐related disorders, alter collagen and induce pr...

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Detalles Bibliográficos
Autores principales:	Hoy, Robert C., D'Erminio, Danielle N., Krishnamoorthy, Divya, Natelson, Devorah M., Laudier, Damien M., Illien‐Jünger, Svenja, Iatridis, James C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Special Issue PSRS Conference 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770195/ https://www.ncbi.nlm.nih.gov/pubmed/33392460 http://dx.doi.org/10.1002/jsp2.1126

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