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Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats
BACKGROUND: The therapeutic effects of antipsychotic drugs (APDs) are mainly attributed to their postsynaptic inhibitory functions on the dopamine D2 receptor, which, however, cannot explain the delayed onset of full therapeutic efficacy. It was previously shown that APDs accumulate in presynaptic v...
Autores principales: | Uzuneser, Taygun C, Weiss, Eva-Maria, Dahlmanns, Jana, Kalinichenko, Liubov S, Amato, Davide, Kornhuber, Johannes, Alzheimer, Christian, Hellmann, Jan, Kaindl, Jonas, Hübner, Harald, Löber, Stefan, Gmeiner, Peter, Grömer, Teja W, Müller, Christian P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770212/ https://www.ncbi.nlm.nih.gov/pubmed/33274688 http://dx.doi.org/10.1177/0269881120965908 |
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