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A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility

Traveler’s diarrhea (TD) is a recurrent and significant issue for many travelers including the military. While many known enteric pathogens exist that are causative agents of diarrhea, our gut microbiome may also play a role in TD susceptibility. To this end, we conducted a pilot study of the microb...

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Autores principales: Stamps, Blake W., Lyon, Wanda J., Irvin, Adam P., Kelley-Loughnane, Nancy, Goodson, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770225/
https://www.ncbi.nlm.nih.gov/pubmed/33384968
http://dx.doi.org/10.3389/fcimb.2020.589297
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author Stamps, Blake W.
Lyon, Wanda J.
Irvin, Adam P.
Kelley-Loughnane, Nancy
Goodson, Michael S.
author_facet Stamps, Blake W.
Lyon, Wanda J.
Irvin, Adam P.
Kelley-Loughnane, Nancy
Goodson, Michael S.
author_sort Stamps, Blake W.
collection PubMed
description Traveler’s diarrhea (TD) is a recurrent and significant issue for many travelers including the military. While many known enteric pathogens exist that are causative agents of diarrhea, our gut microbiome may also play a role in TD susceptibility. To this end, we conducted a pilot study of the microbiome of warfighters prior to- and after deployment overseas to identify marker taxa relevant to TD. This initial study utilized full-length 16S rRNA gene sequencing to provide additional taxonomic resolution toward identifying predictive taxa.16S rRNA analyses of pre- and post-deployment fecal samples identified multiple marker taxa as significantly differentially abundant in subjects that reported diarrhea, including Weissella, Butyrivibrio, Corynebacterium, uncultivated Erysipelotrichaceae, Jeotgallibaca, unclassified Ktedonobacteriaceae, Leptolinea, and uncultivated Ruminiococcaceae. The ability to identify TD risk prior to travel will inform prevention and mitigation strategies to influence diarrhea susceptibility while traveling.
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spelling pubmed-77702252020-12-30 A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility Stamps, Blake W. Lyon, Wanda J. Irvin, Adam P. Kelley-Loughnane, Nancy Goodson, Michael S. Front Cell Infect Microbiol Cellular and Infection Microbiology Traveler’s diarrhea (TD) is a recurrent and significant issue for many travelers including the military. While many known enteric pathogens exist that are causative agents of diarrhea, our gut microbiome may also play a role in TD susceptibility. To this end, we conducted a pilot study of the microbiome of warfighters prior to- and after deployment overseas to identify marker taxa relevant to TD. This initial study utilized full-length 16S rRNA gene sequencing to provide additional taxonomic resolution toward identifying predictive taxa.16S rRNA analyses of pre- and post-deployment fecal samples identified multiple marker taxa as significantly differentially abundant in subjects that reported diarrhea, including Weissella, Butyrivibrio, Corynebacterium, uncultivated Erysipelotrichaceae, Jeotgallibaca, unclassified Ktedonobacteriaceae, Leptolinea, and uncultivated Ruminiococcaceae. The ability to identify TD risk prior to travel will inform prevention and mitigation strategies to influence diarrhea susceptibility while traveling. Frontiers Media S.A. 2020-12-15 /pmc/articles/PMC7770225/ /pubmed/33384968 http://dx.doi.org/10.3389/fcimb.2020.589297 Text en Copyright © 2020 Stamps, Lyon, Irvin, Kelley-Loughnane and Goodson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Stamps, Blake W.
Lyon, Wanda J.
Irvin, Adam P.
Kelley-Loughnane, Nancy
Goodson, Michael S.
A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
title A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
title_full A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
title_fullStr A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
title_full_unstemmed A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
title_short A Pilot Study of the Effect of Deployment on the Gut Microbiome and Traveler’s Diarrhea Susceptibility
title_sort pilot study of the effect of deployment on the gut microbiome and traveler’s diarrhea susceptibility
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770225/
https://www.ncbi.nlm.nih.gov/pubmed/33384968
http://dx.doi.org/10.3389/fcimb.2020.589297
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