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Association between season of vaccination and antibody levels against infectious diseases

Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded dat...

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Autores principales: Abreu, T. C., Boshuizen, H., Mollema, L., Berbers, G. A. M., Korthals Altes, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770373/
https://www.ncbi.nlm.nih.gov/pubmed/33148351
http://dx.doi.org/10.1017/S0950268820002691
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author Abreu, T. C.
Boshuizen, H.
Mollema, L.
Berbers, G. A. M.
Korthals Altes, H.
author_facet Abreu, T. C.
Boshuizen, H.
Mollema, L.
Berbers, G. A. M.
Korthals Altes, H.
author_sort Abreu, T. C.
collection PubMed
description Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded data to investigate whether season of vaccination was associated with antibody responses induced by DT-IPV (diphtheria, tetanus and poliomyelitis), MMR (measles, mumps and rubella) and meningococcus C (MenC) vaccines in children. In total, 434 children met the inclusion criteria to study DT-IPV immunity, 811 for MMR and 311 for MenC. Differences in log(antibody levels) by season of vaccination were investigated with linear multivariable regression analyses. Seroconversion rates varied according to season of vaccination for rubella (90% of autumn-vaccinated children vs. 99% of winter-vaccinated had concentrations above cut-off levels). Summer-vaccinated boys showed a slower decline of tetanus antibodies (6% per month), in comparison with winter-vaccinated boys. In conclusion, season of vaccination showed little association with immunological protection. However, a number of associations were seen with a P-value of about 0.03; and adding data from a just-completed nationwide serological study might add more power to the current study. Further immunological and longitudinal investigations could help understand the mechanisms of seasonal influence in vaccine-induced responses.
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spelling pubmed-77703732021-01-15 Association between season of vaccination and antibody levels against infectious diseases Abreu, T. C. Boshuizen, H. Mollema, L. Berbers, G. A. M. Korthals Altes, H. Epidemiol Infect Original Paper Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded data to investigate whether season of vaccination was associated with antibody responses induced by DT-IPV (diphtheria, tetanus and poliomyelitis), MMR (measles, mumps and rubella) and meningococcus C (MenC) vaccines in children. In total, 434 children met the inclusion criteria to study DT-IPV immunity, 811 for MMR and 311 for MenC. Differences in log(antibody levels) by season of vaccination were investigated with linear multivariable regression analyses. Seroconversion rates varied according to season of vaccination for rubella (90% of autumn-vaccinated children vs. 99% of winter-vaccinated had concentrations above cut-off levels). Summer-vaccinated boys showed a slower decline of tetanus antibodies (6% per month), in comparison with winter-vaccinated boys. In conclusion, season of vaccination showed little association with immunological protection. However, a number of associations were seen with a P-value of about 0.03; and adding data from a just-completed nationwide serological study might add more power to the current study. Further immunological and longitudinal investigations could help understand the mechanisms of seasonal influence in vaccine-induced responses. Cambridge University Press 2020-11-05 /pmc/articles/PMC7770373/ /pubmed/33148351 http://dx.doi.org/10.1017/S0950268820002691 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Abreu, T. C.
Boshuizen, H.
Mollema, L.
Berbers, G. A. M.
Korthals Altes, H.
Association between season of vaccination and antibody levels against infectious diseases
title Association between season of vaccination and antibody levels against infectious diseases
title_full Association between season of vaccination and antibody levels against infectious diseases
title_fullStr Association between season of vaccination and antibody levels against infectious diseases
title_full_unstemmed Association between season of vaccination and antibody levels against infectious diseases
title_short Association between season of vaccination and antibody levels against infectious diseases
title_sort association between season of vaccination and antibody levels against infectious diseases
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770373/
https://www.ncbi.nlm.nih.gov/pubmed/33148351
http://dx.doi.org/10.1017/S0950268820002691
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