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Differences in breast cancer risk after benign breast disease by type of screening diagnosis
INTRODUCTION: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. MATERIALS AND METHODS: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer sc...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770442/ https://www.ncbi.nlm.nih.gov/pubmed/33023825 http://dx.doi.org/10.1016/j.breast.2020.09.005 |
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author | Louro, Javier Román, Marta Posso, Margarita Comerma, Laura Vidal, Carmen Saladié, Francina Alcantara, Rodrigo Sanchez, Mar Quintana, M. Jesús del Riego, Javier Ferrer, Joana Peñalva, Lupe Bargalló, Xavier Prieto, Miguel Sala, María Castells, Xavier |
author_facet | Louro, Javier Román, Marta Posso, Margarita Comerma, Laura Vidal, Carmen Saladié, Francina Alcantara, Rodrigo Sanchez, Mar Quintana, M. Jesús del Riego, Javier Ferrer, Joana Peñalva, Lupe Bargalló, Xavier Prieto, Miguel Sala, María Castells, Xavier |
author_sort | Louro, Javier |
collection | PubMed |
description | INTRODUCTION: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. MATERIALS AND METHODS: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. RESULTS: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24–3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57–2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09–9.08, and 3.35; 95%CI: 1.51–7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95–2.93, and 1.63; 95%CI: 1.32–2.02 for those diagnosed at incident and prevalent screens, respectively). CONCLUSION: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis. |
format | Online Article Text |
id | pubmed-7770442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77704422020-12-30 Differences in breast cancer risk after benign breast disease by type of screening diagnosis Louro, Javier Román, Marta Posso, Margarita Comerma, Laura Vidal, Carmen Saladié, Francina Alcantara, Rodrigo Sanchez, Mar Quintana, M. Jesús del Riego, Javier Ferrer, Joana Peñalva, Lupe Bargalló, Xavier Prieto, Miguel Sala, María Castells, Xavier Breast Original Article INTRODUCTION: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. MATERIALS AND METHODS: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. RESULTS: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24–3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57–2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09–9.08, and 3.35; 95%CI: 1.51–7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95–2.93, and 1.63; 95%CI: 1.32–2.02 for those diagnosed at incident and prevalent screens, respectively). CONCLUSION: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis. Elsevier 2020-10-03 /pmc/articles/PMC7770442/ /pubmed/33023825 http://dx.doi.org/10.1016/j.breast.2020.09.005 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Louro, Javier Román, Marta Posso, Margarita Comerma, Laura Vidal, Carmen Saladié, Francina Alcantara, Rodrigo Sanchez, Mar Quintana, M. Jesús del Riego, Javier Ferrer, Joana Peñalva, Lupe Bargalló, Xavier Prieto, Miguel Sala, María Castells, Xavier Differences in breast cancer risk after benign breast disease by type of screening diagnosis |
title | Differences in breast cancer risk after benign breast disease by type of screening diagnosis |
title_full | Differences in breast cancer risk after benign breast disease by type of screening diagnosis |
title_fullStr | Differences in breast cancer risk after benign breast disease by type of screening diagnosis |
title_full_unstemmed | Differences in breast cancer risk after benign breast disease by type of screening diagnosis |
title_short | Differences in breast cancer risk after benign breast disease by type of screening diagnosis |
title_sort | differences in breast cancer risk after benign breast disease by type of screening diagnosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770442/ https://www.ncbi.nlm.nih.gov/pubmed/33023825 http://dx.doi.org/10.1016/j.breast.2020.09.005 |
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