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A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to pre...

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Autores principales: Rangel-Zuñiga, Oriol Alberto, Vals-Delgado, Cristina, Alcala-Diaz, Juan Francisco, Quintana-Navarro, Gracia M., Krylova, Yelizaveta, Leon-Acuña, Ana, Luque, Raul Miguel, Gomez-Delgado, Francisco, Delgado-Lista, Javier, Ordovas, Jose Maria, Perez-Martinez, Pablo, Camargo, Antonio, Lopez-Miranda, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770508/
https://www.ncbi.nlm.nih.gov/pubmed/33425484
http://dx.doi.org/10.1016/j.omtn.2020.11.001
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author Rangel-Zuñiga, Oriol Alberto
Vals-Delgado, Cristina
Alcala-Diaz, Juan Francisco
Quintana-Navarro, Gracia M.
Krylova, Yelizaveta
Leon-Acuña, Ana
Luque, Raul Miguel
Gomez-Delgado, Francisco
Delgado-Lista, Javier
Ordovas, Jose Maria
Perez-Martinez, Pablo
Camargo, Antonio
Lopez-Miranda, Jose
author_facet Rangel-Zuñiga, Oriol Alberto
Vals-Delgado, Cristina
Alcala-Diaz, Juan Francisco
Quintana-Navarro, Gracia M.
Krylova, Yelizaveta
Leon-Acuña, Ana
Luque, Raul Miguel
Gomez-Delgado, Francisco
Delgado-Lista, Javier
Ordovas, Jose Maria
Perez-Martinez, Pablo
Camargo, Antonio
Lopez-Miranda, Jose
author_sort Rangel-Zuñiga, Oriol Alberto
collection PubMed
description MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease. We included the newly diagnosed T2DM (n = 190) of the 1,002 patients from the CORDIOPREV study. Seventy-three patients reverted from T2DM after 5 years of dietary intervention with a low-fat or Mediterranean diet. Plasma levels of 56 miRNAs were measured by OpenArray. Generalized linear model, receiver operating characteristic (ROC), Cox regression, and pathway analyses were performed. ROC analysis based on clinical variables showed an area under the curve (AUC) of 0.66. After a linear regression analysis, seven miRNAs were identified as the most important variables in the group’s differentiation. The addition of these miRNAs to clinical variables showed an AUC of 0.79. Cox regression analysis using a T2DM remission score including miRNAs showed that high-score patients have a higher probability of T2DM remission (hazard ratio [HR](low versus high), 4.44). Finally, 26 genes involved in 10 pathways were related to the miRNAs. We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease.
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spelling pubmed-77705082021-01-08 A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study Rangel-Zuñiga, Oriol Alberto Vals-Delgado, Cristina Alcala-Diaz, Juan Francisco Quintana-Navarro, Gracia M. Krylova, Yelizaveta Leon-Acuña, Ana Luque, Raul Miguel Gomez-Delgado, Francisco Delgado-Lista, Javier Ordovas, Jose Maria Perez-Martinez, Pablo Camargo, Antonio Lopez-Miranda, Jose Mol Ther Nucleic Acids Original Article MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease. We included the newly diagnosed T2DM (n = 190) of the 1,002 patients from the CORDIOPREV study. Seventy-three patients reverted from T2DM after 5 years of dietary intervention with a low-fat or Mediterranean diet. Plasma levels of 56 miRNAs were measured by OpenArray. Generalized linear model, receiver operating characteristic (ROC), Cox regression, and pathway analyses were performed. ROC analysis based on clinical variables showed an area under the curve (AUC) of 0.66. After a linear regression analysis, seven miRNAs were identified as the most important variables in the group’s differentiation. The addition of these miRNAs to clinical variables showed an AUC of 0.79. Cox regression analysis using a T2DM remission score including miRNAs showed that high-score patients have a higher probability of T2DM remission (hazard ratio [HR](low versus high), 4.44). Finally, 26 genes involved in 10 pathways were related to the miRNAs. We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. American Society of Gene & Cell Therapy 2020-11-11 /pmc/articles/PMC7770508/ /pubmed/33425484 http://dx.doi.org/10.1016/j.omtn.2020.11.001 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Rangel-Zuñiga, Oriol Alberto
Vals-Delgado, Cristina
Alcala-Diaz, Juan Francisco
Quintana-Navarro, Gracia M.
Krylova, Yelizaveta
Leon-Acuña, Ana
Luque, Raul Miguel
Gomez-Delgado, Francisco
Delgado-Lista, Javier
Ordovas, Jose Maria
Perez-Martinez, Pablo
Camargo, Antonio
Lopez-Miranda, Jose
A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
title A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
title_full A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
title_fullStr A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
title_full_unstemmed A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
title_short A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study
title_sort set of mirnas predicts t2dm remission in patients with coronary heart disease: from the cordioprev study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770508/
https://www.ncbi.nlm.nih.gov/pubmed/33425484
http://dx.doi.org/10.1016/j.omtn.2020.11.001
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