Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead

Neuroendocrine tumors, or NETs, are cancer originating in neuroendocrine cells. They are mostly found in the gastrointestinal tract or lungs. Functional NETs are characterized by signs and symptoms caused by the oversecretion of hormones and other substances, but most NETs are non-functioning and di...

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Autores principales: Colao, Annamaria, de Nigris, Filomena, Modica, Roberta, Napoli, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770585/
https://www.ncbi.nlm.nih.gov/pubmed/33384663
http://dx.doi.org/10.3389/fendo.2020.604341
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author Colao, Annamaria
de Nigris, Filomena
Modica, Roberta
Napoli, Claudio
author_facet Colao, Annamaria
de Nigris, Filomena
Modica, Roberta
Napoli, Claudio
author_sort Colao, Annamaria
collection PubMed
description Neuroendocrine tumors, or NETs, are cancer originating in neuroendocrine cells. They are mostly found in the gastrointestinal tract or lungs. Functional NETs are characterized by signs and symptoms caused by the oversecretion of hormones and other substances, but most NETs are non-functioning and diagnosis in advanced stages is common. Thus, novel diagnostic and therapeutic strategies are warranted. Epigenetics may contribute to refining the diagnosis, as well as to identify targeted therapy interfering with epigenetic-sensitive pathways. The goal of this review was to discuss the recent advancement in the epigenetic characterization of NETs highlighting their role in clinical findings.
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spelling pubmed-77705852020-12-30 Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead Colao, Annamaria de Nigris, Filomena Modica, Roberta Napoli, Claudio Front Endocrinol (Lausanne) Endocrinology Neuroendocrine tumors, or NETs, are cancer originating in neuroendocrine cells. They are mostly found in the gastrointestinal tract or lungs. Functional NETs are characterized by signs and symptoms caused by the oversecretion of hormones and other substances, but most NETs are non-functioning and diagnosis in advanced stages is common. Thus, novel diagnostic and therapeutic strategies are warranted. Epigenetics may contribute to refining the diagnosis, as well as to identify targeted therapy interfering with epigenetic-sensitive pathways. The goal of this review was to discuss the recent advancement in the epigenetic characterization of NETs highlighting their role in clinical findings. Frontiers Media S.A. 2020-12-15 /pmc/articles/PMC7770585/ /pubmed/33384663 http://dx.doi.org/10.3389/fendo.2020.604341 Text en Copyright © 2020 Colao, de Nigris, Modica and Napoli http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Colao, Annamaria
de Nigris, Filomena
Modica, Roberta
Napoli, Claudio
Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
title Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
title_full Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
title_fullStr Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
title_full_unstemmed Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
title_short Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead
title_sort clinical epigenetics of neuroendocrine tumors: the road ahead
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770585/
https://www.ncbi.nlm.nih.gov/pubmed/33384663
http://dx.doi.org/10.3389/fendo.2020.604341
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