The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke

It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the b...

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Autores principales: Kang, Ruiqing, Gamdzyk, Marcin, Lenahan, Cameron, Tang, Jiping, Tan, Sheng, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770642/
https://www.ncbi.nlm.nih.gov/pubmed/32469699
http://dx.doi.org/10.2174/1570159X18666200529150907
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author Kang, Ruiqing
Gamdzyk, Marcin
Lenahan, Cameron
Tang, Jiping
Tan, Sheng
Zhang, John H.
author_facet Kang, Ruiqing
Gamdzyk, Marcin
Lenahan, Cameron
Tang, Jiping
Tan, Sheng
Zhang, John H.
author_sort Kang, Ruiqing
collection PubMed
description It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the brain, play a vital role in BBB function. M1 microglia worsen BBB disruption, while M2 microglia assist in repairing BBB damage. Microglia can also directly interact with endothelial cells and affect BBB permeability. In this review, we are going to discuss the mechanisms responsible for the dual role of microglia in BBB dysfunction after stroke.
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spelling pubmed-77706422021-06-01 The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke Kang, Ruiqing Gamdzyk, Marcin Lenahan, Cameron Tang, Jiping Tan, Sheng Zhang, John H. Curr Neuropharmacol Article It is well-known that stroke is one of the leading causes of death and disability all over the world. After a stroke, the blood-brain barrier subsequently breaks down. The BBB consists of endothelial cells surrounded by astrocytes. Microglia, considered the long-living resident immune cells of the brain, play a vital role in BBB function. M1 microglia worsen BBB disruption, while M2 microglia assist in repairing BBB damage. Microglia can also directly interact with endothelial cells and affect BBB permeability. In this review, we are going to discuss the mechanisms responsible for the dual role of microglia in BBB dysfunction after stroke. Bentham Science Publishers 2020-12 2020-12 /pmc/articles/PMC7770642/ /pubmed/32469699 http://dx.doi.org/10.2174/1570159X18666200529150907 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Kang, Ruiqing
Gamdzyk, Marcin
Lenahan, Cameron
Tang, Jiping
Tan, Sheng
Zhang, John H.
The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
title The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
title_full The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
title_fullStr The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
title_full_unstemmed The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
title_short The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke
title_sort dual role of microglia in blood-brain barrier dysfunction after stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770642/
https://www.ncbi.nlm.nih.gov/pubmed/32469699
http://dx.doi.org/10.2174/1570159X18666200529150907
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