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The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm

Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, suc...

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Detalles Bibliográficos
Autores principales: Zhang, Siyuan, Xin, Fan, Zhang, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770649/
https://www.ncbi.nlm.nih.gov/pubmed/33385116
http://dx.doi.org/10.1016/j.isci.2020.101915
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author Zhang, Siyuan
Xin, Fan
Zhang, Xiaobo
author_facet Zhang, Siyuan
Xin, Fan
Zhang, Xiaobo
author_sort Zhang, Siyuan
collection PubMed
description Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells.
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spelling pubmed-77706492020-12-30 The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm Zhang, Siyuan Xin, Fan Zhang, Xiaobo iScience Article Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells. Elsevier 2020-12-09 /pmc/articles/PMC7770649/ /pubmed/33385116 http://dx.doi.org/10.1016/j.isci.2020.101915 Text en © 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Zhang, Siyuan
Xin, Fan
Zhang, Xiaobo
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
title The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
title_full The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
title_fullStr The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
title_full_unstemmed The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
title_short The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
title_sort compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770649/
https://www.ncbi.nlm.nih.gov/pubmed/33385116
http://dx.doi.org/10.1016/j.isci.2020.101915
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