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The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, suc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770649/ https://www.ncbi.nlm.nih.gov/pubmed/33385116 http://dx.doi.org/10.1016/j.isci.2020.101915 |
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author | Zhang, Siyuan Xin, Fan Zhang, Xiaobo |
author_facet | Zhang, Siyuan Xin, Fan Zhang, Xiaobo |
author_sort | Zhang, Siyuan |
collection | PubMed |
description | Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells. |
format | Online Article Text |
id | pubmed-7770649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77706492020-12-30 The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm Zhang, Siyuan Xin, Fan Zhang, Xiaobo iScience Article Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells. Elsevier 2020-12-09 /pmc/articles/PMC7770649/ /pubmed/33385116 http://dx.doi.org/10.1016/j.isci.2020.101915 Text en © 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Zhang, Siyuan Xin, Fan Zhang, Xiaobo The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title | The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_full | The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_fullStr | The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_full_unstemmed | The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_short | The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_sort | compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770649/ https://www.ncbi.nlm.nih.gov/pubmed/33385116 http://dx.doi.org/10.1016/j.isci.2020.101915 |
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