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Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized n...

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Autores principales: Zhang, Songtao, Jin, Longhai, Liu, Jianhua, Liu, Yang, Zhang, Tianqi, Zhao, Ying, Yin, Na, Niu, Rui, Li, Xiaoqing, Xue, Dongzhi, Song, Shuyan, Wang, Yinghui, Zhang, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770794/
https://www.ncbi.nlm.nih.gov/pubmed/34138182
http://dx.doi.org/10.1007/s40820-020-00516-z
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author Zhang, Songtao
Jin, Longhai
Liu, Jianhua
Liu, Yang
Zhang, Tianqi
Zhao, Ying
Yin, Na
Niu, Rui
Li, Xiaoqing
Xue, Dongzhi
Song, Shuyan
Wang, Yinghui
Zhang, Hongjie
author_facet Zhang, Songtao
Jin, Longhai
Liu, Jianhua
Liu, Yang
Zhang, Tianqi
Zhao, Ying
Yin, Na
Niu, Rui
Li, Xiaoqing
Xue, Dongzhi
Song, Shuyan
Wang, Yinghui
Zhang, Hongjie
author_sort Zhang, Songtao
collection PubMed
description In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS(2) nanocomposites modified by bovine serum albumin (FeO/MoS(2)-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS(2) nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS(2) nanosheets not only can accelerate the conversion of Fe(3+) ions to Fe(2+) ions by Mo(4+) ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS(2)-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-020-00516-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-77707942021-06-14 Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light Zhang, Songtao Jin, Longhai Liu, Jianhua Liu, Yang Zhang, Tianqi Zhao, Ying Yin, Na Niu, Rui Li, Xiaoqing Xue, Dongzhi Song, Shuyan Wang, Yinghui Zhang, Hongjie Nanomicro Lett Article In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS(2) nanocomposites modified by bovine serum albumin (FeO/MoS(2)-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS(2) nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS(2) nanosheets not only can accelerate the conversion of Fe(3+) ions to Fe(2+) ions by Mo(4+) ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS(2)-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-020-00516-z) contains supplementary material, which is available to authorized users. Springer Singapore 2020-09-02 /pmc/articles/PMC7770794/ /pubmed/34138182 http://dx.doi.org/10.1007/s40820-020-00516-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Songtao
Jin, Longhai
Liu, Jianhua
Liu, Yang
Zhang, Tianqi
Zhao, Ying
Yin, Na
Niu, Rui
Li, Xiaoqing
Xue, Dongzhi
Song, Shuyan
Wang, Yinghui
Zhang, Hongjie
Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
title Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
title_full Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
title_fullStr Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
title_full_unstemmed Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
title_short Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light
title_sort boosting chemodynamic therapy by the synergistic effect of co-catalyze and photothermal effect triggered by the second near-infrared light
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770794/
https://www.ncbi.nlm.nih.gov/pubmed/34138182
http://dx.doi.org/10.1007/s40820-020-00516-z
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