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Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, the...

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Autores principales: Wu, Xunzhi, Suo, Yongkuan, Shi, Hui, Liu, Ruiqi, Wu, Fengxia, Wang, Tingzhong, Ma, Lina, Liu, Hongguang, Cheng, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770864/
https://www.ncbi.nlm.nih.gov/pubmed/34138257
http://dx.doi.org/10.1007/s40820-020-0378-6
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author Wu, Xunzhi
Suo, Yongkuan
Shi, Hui
Liu, Ruiqi
Wu, Fengxia
Wang, Tingzhong
Ma, Lina
Liu, Hongguang
Cheng, Zhen
author_facet Wu, Xunzhi
Suo, Yongkuan
Shi, Hui
Liu, Ruiqi
Wu, Fengxia
Wang, Tingzhong
Ma, Lina
Liu, Hongguang
Cheng, Zhen
author_sort Wu, Xunzhi
collection PubMed
description Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700 nm) especially NIR-IIa window (1300–1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-020-0378-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-77708642021-06-14 Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window Wu, Xunzhi Suo, Yongkuan Shi, Hui Liu, Ruiqi Wu, Fengxia Wang, Tingzhong Ma, Lina Liu, Hongguang Cheng, Zhen Nanomicro Lett Article Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700 nm) especially NIR-IIa window (1300–1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-020-0378-6) contains supplementary material, which is available to authorized users. Springer Singapore 2020-01-24 /pmc/articles/PMC7770864/ /pubmed/34138257 http://dx.doi.org/10.1007/s40820-020-0378-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wu, Xunzhi
Suo, Yongkuan
Shi, Hui
Liu, Ruiqi
Wu, Fengxia
Wang, Tingzhong
Ma, Lina
Liu, Hongguang
Cheng, Zhen
Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
title Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
title_full Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
title_fullStr Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
title_full_unstemmed Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
title_short Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
title_sort deep-tissue photothermal therapy using laser illumination at nir-iia window
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770864/
https://www.ncbi.nlm.nih.gov/pubmed/34138257
http://dx.doi.org/10.1007/s40820-020-0378-6
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