Cargando…

Characterization of genome-wide association study data reveals spatiotemporal heterogeneity of mental disorders

BACKGROUND: Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BIP), major depressive disorder (MDD), attention deficit-hyperactivity disorder (ADHD), and autism spectrum disorder (ASD) are often related to brain development. Both shared and unique biological and neurodevelopmental...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dai, Yulin, O’Brien, Timothy D., Pei, Guangsheng, Zhao, Zhongming, Jia, Peilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771094/ https://www.ncbi.nlm.nih.gov/pubmed/33371872 http://dx.doi.org/10.1186/s12920-020-00832-8

Ejemplares similares

Gene expression imputation and cell-type deconvolution in human brain with spatiotemporal precision and its implications for brain-related disorders
por: Pei, Guangsheng, et al.
Publicado: (2021)

A Convergent Study of Genetic Variants Associated With Crohn’s Disease: Evidence From GWAS, Gene Expression, Methylation, eQTL and TWAS
por: Dai, Yulin, et al.
Publicado: (2019)

Decoding whole-genome mutational signatures in 37 human pan-cancers by denoising sparse autoencoder neural network
por: Pei, Guangsheng, et al.
Publicado: (2020)

Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics
por: Pei, Guangsheng, et al.
Publicado: (2019)

scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies
por: Jia, Peilin, et al.
Publicado: (2022)

TSEA-DB: a trait–tissue association map for human complex traits and diseases
por: Jia, Peilin, et al.
Publicado: (2020)

Deep generative neural network for accurate drug response imputation
por: Jia, Peilin, et al.
Publicado: (2021)

Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations
por: Pei, Guangsheng, et al.
Publicado: (2020)

deCS: A Tool for Systematic Cell Type Annotations of Single-cell RNA Sequencing Data among Human Tissues
por: Pei, Guangsheng, et al.
Publicado: (2023)

Multiple transcription factors contribute to inter-chromosomal interaction in yeast
por: Dai, Yulin, et al.
Publicado: (2018)

DeepFun: a deep learning sequence-based model to decipher non-coding variant effect in a tissue- and cell type-specific manner
por: Pei, Guangsheng, et al.
Publicado: (2021)

An integrative, genomic, transcriptomic and network-assisted study to identify genes associated with human cleft lip with or without cleft palate
por: Yan, Fangfang, et al.
Publicado: (2020)

Searching joint association signals in CATIE schizophrenia genome-wide association studies through a refined integrative network approach
por: Jia, Peilin, et al.
Publicado: (2012)

Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients
por: Liu, Andi, et al.
Publicado: (2021)

ANCO-GeneDB: annotations and comprehensive analysis of candidate genes for alcohol, nicotine, cocaine and opioid dependence
por: Hu, Ruifeng, et al.
Publicado: (2018)

A Method for Bridging Population-Specific Genotypes to Detect Gene Modules Associated with Alzheimer’s Disease
por: Dai, Yulin, et al.
Publicado: (2022)

Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2
por: Tang, Mengfan, et al.
Publicado: (2021)

Integrative pathway analysis of genome-wide association studies and gene expression data in prostate cancer
por: Jia, Peilin, et al.
Publicado: (2012)

Convergent roles of de novo mutations and common variants in schizophrenia in tissue-specific and spatiotemporal co-expression network
por: Jia, Peilin, et al.
Publicado: (2018)

Delineating COVID-19 immunological features using single-cell RNA sequencing
por: Liu, Wendao, et al.
Publicado: (2022)

Weak sharing of genetic association signals in three lung cancer subtypes: evidence at the SNP, gene, regulation, and pathway levels
por: O’Brien, Timothy D., et al.
Publicado: (2018)

Characterization of Tumor-Suppressor Gene Inactivation Events in 33 Cancer Types
por: Jia, Peilin, et al.
Publicado: (2019)

Pathway- and network-based analysis of GWAS data revealed susceptibility gene sets to schizophrenia
por: Jia, Peilin, et al.
Publicado: (2010)

Transcriptome Sequencing and Genome-wide Association Analyses Reveal Lysosomal Function and Actin Cytoskeleton Remodeling in Schizophrenia and Bipolar Disorder
por: Zhao, Zhongming, et al.
Publicado: (2014)

Gene2vec: distributed representation of genes based on co-expression
por: Du, Jingcheng, et al.
Publicado: (2019)

Dense module searching for gene networks associated with multiple sclerosis
por: Manuel, Astrid M., et al.
Publicado: (2020)

Integrated analysis of racial disparities in genomic architecture identifies a trans‐ancestry prognostic subtype in bladder cancer
por: Zhang, Baifeng, et al.
Publicado: (2022)

Association of CXCR6 with COVID-19 severity: Delineating the host genetic factors in transcriptomic regulation
por: Dai, Yulin, et al.
Publicado: (2021)

CSEA-DB: an omnibus for human complex trait and cell type associations
por: Dai, Yulin, et al.
Publicado: (2020)

Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation
por: Dai, Yulin, et al.
Publicado: (2021)

Single-cell RNA sequencing reveals a strong connection between Gadd45g upregulation and oncolytic HSV infection in tumor tissue
por: Ravirala, Divya, et al.
Publicado: (2021)

Investigating cellular heterogeneity at the single-cell level by the flexible and mobile extrachromosomal circular DNA
por: Kang, Jiajinlong, et al.
Publicado: (2023)

Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia
por: Jia, Peilin, et al.
Publicado: (2012)

Single-cell analysis reveals gene-expression heterogeneity in syntrophic dual-culture of Desulfovibrio vulgaris with Methanosarcina barkeri
por: Qi, Zhenhua, et al.
Publicado: (2014)

STED-FLCS: An Advanced Tool to Reveal Spatiotemporal Heterogeneity of Molecular Membrane Dynamics
por: Vicidomini, Giuseppe, et al.
Publicado: (2015)

VERSE: a novel approach to detect virus integration in host genomes through reference genome customization
por: Wang, Qingguo, et al.
Publicado: (2015)

Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy
por: Cheng, Feixiong, et al.
Publicado: (2014)

Spatiotemporal heterogeneity of land subsidence in Beijing
por: Duan, Guangyao, et al.
Publicado: (2022)

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
por: Feng, Xu, et al.
Publicado: (2022)

Causal Inference of Genetic Variants and Genes in Amyotrophic Lateral Sclerosis
por: Pan, Siyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i63p1tcot8a8619j32f2o5di7c