Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

Matrix metalloproteinases (MMPs) contribute to many physiological and pathological phenomena via the proteolysis of extracellular matrix components. Specific blocking of the active site of each MMP sheds light on its particular role. However, it remains difficult to acquire an active-site inhibitor...

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Detalles Bibliográficos
Autores principales: Yano, Hidenori, Nishimiya, Daisuke, Kawaguchi, Yoshirou, Tamura, Masakazu, Hashimoto, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771667/
https://www.ncbi.nlm.nih.gov/pubmed/33373399
http://dx.doi.org/10.1371/journal.pone.0244656

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