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Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas

BACKGROUND: Carboplatin is a potent cytoreductive agent for a variety of solid tumors. However, when delivered systemically, clinical efficacy for the treatment of high grade gliomas is poor due to limited penetration across the blood-brain barrier (BBB). Direct intracerebral (IC) convection-enhance...

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Detalles Bibliográficos
Autores principales:	Wang, Joshua L., Barth, Rolf F., Cavaliere, Robert, Puduvalli, Vinay K., Giglio, Pierre, Lonser, Russell R., Elder, J. Bradley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771668/ https://www.ncbi.nlm.nih.gov/pubmed/33373402 http://dx.doi.org/10.1371/journal.pone.0244383

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