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The mechanisms behind perivascular fluid flow

Flow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscil...

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Autores principales: Daversin-Catty, Cécile, Vinje, Vegard, Mardal, Kent-André, Rognes, Marie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771676/
https://www.ncbi.nlm.nih.gov/pubmed/33373419
http://dx.doi.org/10.1371/journal.pone.0244442
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author Daversin-Catty, Cécile
Vinje, Vegard
Mardal, Kent-André
Rognes, Marie E.
author_facet Daversin-Catty, Cécile
Vinje, Vegard
Mardal, Kent-André
Rognes, Marie E.
author_sort Daversin-Catty, Cécile
collection PubMed
description Flow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscillatory particle movement has a clear cardiac component, while the mechanisms involved in net movement remain disputed. Using computational fluid dynamics, we computed the CSF velocity and pressure in a PVS surrounding a cerebral artery subject to different forces, representing arterial wall expansion, systemic CSF pressure changes and rigid motions of the artery. The arterial wall expansion generated velocity amplitudes of 60–260 μm/s, which is in the upper range of previously observed values. In the absence of a static pressure gradient, predicted net flow velocities were small (<0.5 μm/s), though reaching up to 7 μm/s for non-physiological PVS lengths. In realistic geometries, a static systemic pressure increase of physiologically plausible magnitude was sufficient to induce net flow velocities of 20–30 μm/s. Moreover, rigid motions of the artery added to the complexity of flow patterns in the PVS. Our study demonstrates that the combination of arterial wall expansion, rigid motions and a static CSF pressure gradient generates net and oscillatory PVS flow, quantitatively comparable with experimental findings. The static CSF pressure gradient required for net flow is small, suggesting that its origin is yet to be determined.
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spelling pubmed-77716762021-01-08 The mechanisms behind perivascular fluid flow Daversin-Catty, Cécile Vinje, Vegard Mardal, Kent-André Rognes, Marie E. PLoS One Research Article Flow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscillatory particle movement has a clear cardiac component, while the mechanisms involved in net movement remain disputed. Using computational fluid dynamics, we computed the CSF velocity and pressure in a PVS surrounding a cerebral artery subject to different forces, representing arterial wall expansion, systemic CSF pressure changes and rigid motions of the artery. The arterial wall expansion generated velocity amplitudes of 60–260 μm/s, which is in the upper range of previously observed values. In the absence of a static pressure gradient, predicted net flow velocities were small (<0.5 μm/s), though reaching up to 7 μm/s for non-physiological PVS lengths. In realistic geometries, a static systemic pressure increase of physiologically plausible magnitude was sufficient to induce net flow velocities of 20–30 μm/s. Moreover, rigid motions of the artery added to the complexity of flow patterns in the PVS. Our study demonstrates that the combination of arterial wall expansion, rigid motions and a static CSF pressure gradient generates net and oscillatory PVS flow, quantitatively comparable with experimental findings. The static CSF pressure gradient required for net flow is small, suggesting that its origin is yet to be determined. Public Library of Science 2020-12-29 /pmc/articles/PMC7771676/ /pubmed/33373419 http://dx.doi.org/10.1371/journal.pone.0244442 Text en © 2020 Daversin-Catty et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Daversin-Catty, Cécile
Vinje, Vegard
Mardal, Kent-André
Rognes, Marie E.
The mechanisms behind perivascular fluid flow
title The mechanisms behind perivascular fluid flow
title_full The mechanisms behind perivascular fluid flow
title_fullStr The mechanisms behind perivascular fluid flow
title_full_unstemmed The mechanisms behind perivascular fluid flow
title_short The mechanisms behind perivascular fluid flow
title_sort mechanisms behind perivascular fluid flow
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771676/
https://www.ncbi.nlm.nih.gov/pubmed/33373419
http://dx.doi.org/10.1371/journal.pone.0244442
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