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Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction

BACKGROUND: Wild edible plants are good sources for bioactive compounds, vitamins, and minerals with various applications. They can play a role in supporting the immune system and are highly beneficial as resources. Suaeda monoica Forssk is a wild edible plant that grows in Iraq and it’s biological...

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Autores principales: Al-Shawi, Ali A. A., Hameed, Mustafa Fadhil, Ali, Nashwan Hussein, Hussein, Kawkab Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771932/
https://www.ncbi.nlm.nih.gov/pubmed/32856865
http://dx.doi.org/10.31557/APJCP.2020.21.8.2349
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author Al-Shawi, Ali A. A.
Hameed, Mustafa Fadhil
Ali, Nashwan Hussein
Hussein, Kawkab Ali
author_facet Al-Shawi, Ali A. A.
Hameed, Mustafa Fadhil
Ali, Nashwan Hussein
Hussein, Kawkab Ali
author_sort Al-Shawi, Ali A. A.
collection PubMed
description BACKGROUND: Wild edible plants are good sources for bioactive compounds, vitamins, and minerals with various applications. They can play a role in supporting the immune system and are highly beneficial as resources. Suaeda monoica Forssk is a wild edible plant that grows in Iraq and it’s biological activities have not yet reported. METHODS: Saueda monoica Forssk bioactive compounds were extracted by a microwave-assisted extraction method using ethanol as a solvent, and its chemical composition was analyzed by GC-MS. The biological activities were evaluated via antioxidant, anti-liver-cancer, antibacterial, and toxicity tests in vitro. RESULTS: The results of GC-MS analysis showed that there were about 20 bioactive compounds. The most abundant compound was N,N-Dimethylglycine methyl ester, followed by 9,12,15-Octadecatrienoic acid, n-Hexadecanoic acid, and N,N-Dimethylglycine. The antioxidant activity of the ethanol extract of the plant showed a significant IC(50). The extract of S. monoica against liver cancer cells (HCAM) showed significant toxicity. Flow cytometric analysis showed a significant induced apoptosis and cell cycle arrested at G1 phase. CONCLUSIONS: The results indicated the significance of the components of Iraqi S. monoica Forssk by MAE method as a potential food supplement in nutrition systems to prevent liver cancer and enhance the liver’s defense against diseases.
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spelling pubmed-77719322021-02-06 Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction Al-Shawi, Ali A. A. Hameed, Mustafa Fadhil Ali, Nashwan Hussein Hussein, Kawkab Ali Asian Pac J Cancer Prev Research Article BACKGROUND: Wild edible plants are good sources for bioactive compounds, vitamins, and minerals with various applications. They can play a role in supporting the immune system and are highly beneficial as resources. Suaeda monoica Forssk is a wild edible plant that grows in Iraq and it’s biological activities have not yet reported. METHODS: Saueda monoica Forssk bioactive compounds were extracted by a microwave-assisted extraction method using ethanol as a solvent, and its chemical composition was analyzed by GC-MS. The biological activities were evaluated via antioxidant, anti-liver-cancer, antibacterial, and toxicity tests in vitro. RESULTS: The results of GC-MS analysis showed that there were about 20 bioactive compounds. The most abundant compound was N,N-Dimethylglycine methyl ester, followed by 9,12,15-Octadecatrienoic acid, n-Hexadecanoic acid, and N,N-Dimethylglycine. The antioxidant activity of the ethanol extract of the plant showed a significant IC(50). The extract of S. monoica against liver cancer cells (HCAM) showed significant toxicity. Flow cytometric analysis showed a significant induced apoptosis and cell cycle arrested at G1 phase. CONCLUSIONS: The results indicated the significance of the components of Iraqi S. monoica Forssk by MAE method as a potential food supplement in nutrition systems to prevent liver cancer and enhance the liver’s defense against diseases. West Asia Organization for Cancer Prevention 2020-08 /pmc/articles/PMC7771932/ /pubmed/32856865 http://dx.doi.org/10.31557/APJCP.2020.21.8.2349 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al-Shawi, Ali A. A.
Hameed, Mustafa Fadhil
Ali, Nashwan Hussein
Hussein, Kawkab Ali
Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction
title Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction
title_full Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction
title_fullStr Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction
title_full_unstemmed Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction
title_short Investigations of Phytoconstituents, Antioxidant and Anti-Liver Cancer Activities of Saueda monoica Forssk Extracted by Microwave-Assisted Extraction
title_sort investigations of phytoconstituents, antioxidant and anti-liver cancer activities of saueda monoica forssk extracted by microwave-assisted extraction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771932/
https://www.ncbi.nlm.nih.gov/pubmed/32856865
http://dx.doi.org/10.31557/APJCP.2020.21.8.2349
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