Cargando…
Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
OBJECTIVE: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluate...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771946/ https://www.ncbi.nlm.nih.gov/pubmed/32856868 http://dx.doi.org/10.31557/APJCP.2020.21.8.2373 |
_version_ | 1783629774791376896 |
---|---|
author | Ito, Tokuji Shinkawa, Hiroji Takemura, Shigekazu Tanaka, Shogo Nishioka, Takayoshi Miyazaki, Toru Ishihara, Atsushi Kubo, Shoji |
author_facet | Ito, Tokuji Shinkawa, Hiroji Takemura, Shigekazu Tanaka, Shogo Nishioka, Takayoshi Miyazaki, Toru Ishihara, Atsushi Kubo, Shoji |
author_sort | Ito, Tokuji |
collection | PubMed |
description | OBJECTIVE: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. RESULTS: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). CONCLUSION: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC. |
format | Online Article Text |
id | pubmed-7771946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-77719462021-02-06 Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma Ito, Tokuji Shinkawa, Hiroji Takemura, Shigekazu Tanaka, Shogo Nishioka, Takayoshi Miyazaki, Toru Ishihara, Atsushi Kubo, Shoji Asian Pac J Cancer Prev Research Article OBJECTIVE: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. RESULTS: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). CONCLUSION: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC. West Asia Organization for Cancer Prevention 2020-08 /pmc/articles/PMC7771946/ /pubmed/32856868 http://dx.doi.org/10.31557/APJCP.2020.21.8.2373 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ito, Tokuji Shinkawa, Hiroji Takemura, Shigekazu Tanaka, Shogo Nishioka, Takayoshi Miyazaki, Toru Ishihara, Atsushi Kubo, Shoji Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma |
title | Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma |
title_full | Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma |
title_fullStr | Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma |
title_full_unstemmed | Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma |
title_short | Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma |
title_sort | impact of the preoperative c-reactive protein to albumin ratio on the long-term outcomes of hepatic resection for intrahepatic cholangiocarcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771946/ https://www.ncbi.nlm.nih.gov/pubmed/32856868 http://dx.doi.org/10.31557/APJCP.2020.21.8.2373 |
work_keys_str_mv | AT itotokuji impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT shinkawahiroji impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT takemurashigekazu impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT tanakashogo impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT nishiokatakayoshi impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT miyazakitoru impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT ishiharaatsushi impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma AT kuboshoji impactofthepreoperativecreactiveproteintoalbuminratioonthelongtermoutcomesofhepaticresectionforintrahepaticcholangiocarcinoma |