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Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma

OBJECTIVE: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluate...

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Autores principales: Ito, Tokuji, Shinkawa, Hiroji, Takemura, Shigekazu, Tanaka, Shogo, Nishioka, Takayoshi, Miyazaki, Toru, Ishihara, Atsushi, Kubo, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771946/
https://www.ncbi.nlm.nih.gov/pubmed/32856868
http://dx.doi.org/10.31557/APJCP.2020.21.8.2373
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author Ito, Tokuji
Shinkawa, Hiroji
Takemura, Shigekazu
Tanaka, Shogo
Nishioka, Takayoshi
Miyazaki, Toru
Ishihara, Atsushi
Kubo, Shoji
author_facet Ito, Tokuji
Shinkawa, Hiroji
Takemura, Shigekazu
Tanaka, Shogo
Nishioka, Takayoshi
Miyazaki, Toru
Ishihara, Atsushi
Kubo, Shoji
author_sort Ito, Tokuji
collection PubMed
description OBJECTIVE: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. RESULTS: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). CONCLUSION: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC.
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spelling pubmed-77719462021-02-06 Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma Ito, Tokuji Shinkawa, Hiroji Takemura, Shigekazu Tanaka, Shogo Nishioka, Takayoshi Miyazaki, Toru Ishihara, Atsushi Kubo, Shoji Asian Pac J Cancer Prev Research Article OBJECTIVE: The present study aimed to investigate the impact of preoperative C-reactive protein to albumin (CRP/Alb) ratio on the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). METHODS: 82 patients who underwent hepatic resection for mass-forming type of ICC were evaluated. The relationship between preoperative CRP/Alb ratio and survival outcomes was investigated. RESULTS: The optimal cutoff value of CRP/Alb ratio for assessing overall survival (OS) was determined as 0.089. Univariate analysis for recurrence-free survival (RFS) showed that CRP/Alb ratio >0.089, carbohydrate antigen 19-9 (CA 19-9) >37 U/mL, lymph node metastasis, vascular invasion, and multiple tumors were significantly associated with postoperative recurrence. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.006), and multiple tumors (p < 0.001). Univariate analysis for OS showed that CRP/Alb ratio >0.089, CA 19-9 >37 U/mL, lymph node metastasis, vascular invasion, multiple tumors, and positive surgical margin were significantly associated with overall death. On multivariate analysis, the independent prognostic factors identified were CRP/Alb ratio >0.089 (p < 0.001), lymph node metastasis (p = 0.01), and multiple tumors (p = 0.005). CONCLUSION: Preoperative CRP/Alb ratio may predict poor long-term outcomes after hepatic resection in patients with ICC. West Asia Organization for Cancer Prevention 2020-08 /pmc/articles/PMC7771946/ /pubmed/32856868 http://dx.doi.org/10.31557/APJCP.2020.21.8.2373 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ito, Tokuji
Shinkawa, Hiroji
Takemura, Shigekazu
Tanaka, Shogo
Nishioka, Takayoshi
Miyazaki, Toru
Ishihara, Atsushi
Kubo, Shoji
Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
title Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
title_full Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
title_fullStr Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
title_full_unstemmed Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
title_short Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma
title_sort impact of the preoperative c-reactive protein to albumin ratio on the long-term outcomes of hepatic resection for intrahepatic cholangiocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771946/
https://www.ncbi.nlm.nih.gov/pubmed/32856868
http://dx.doi.org/10.31557/APJCP.2020.21.8.2373
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