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The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors

Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system's failure. The sensitivity of ferroptosis...

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Autores principales: Zhu, Jinghan, Xiong, Yixiao, Zhang, Yuxin, Wen, Jingyuan, Cai, Ning, Cheng, Kun, Liang, Huifang, Zhang, Wanguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772020/
https://www.ncbi.nlm.nih.gov/pubmed/33425217
http://dx.doi.org/10.1155/2020/8810785
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author Zhu, Jinghan
Xiong, Yixiao
Zhang, Yuxin
Wen, Jingyuan
Cai, Ning
Cheng, Kun
Liang, Huifang
Zhang, Wanguang
author_facet Zhu, Jinghan
Xiong, Yixiao
Zhang, Yuxin
Wen, Jingyuan
Cai, Ning
Cheng, Kun
Liang, Huifang
Zhang, Wanguang
author_sort Zhu, Jinghan
collection PubMed
description Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system's failure. The sensitivity of ferroptosis is tightly regulated by a series of biological processes, the metabolism of iron, amino acids, and polyunsaturated fatty acids, and the interaction of glutathione (GSH), NADPH, coenzyme Q10 (CoQ10), and phospholipids. Elevated oxidative stress (ROS) level is a hallmark of cancer, and ferroptosis serves as a link between nutrition metabolism and redox biology. Targeting ferroptosis may be an effective and selective way for cancer therapy. The underlying molecular mechanism of ferroptosis occurrence is still not enough. This review will briefly summarize the process of ferroptosis and introduce critical molecules in the ferroptotic cascade. Furthermore, we reviewed the occurrence and regulation of reduction-oxidation (redox) for ferroptosis in cancer metabolism. The role of the tumor suppressor and the epigenetic regulator in tumor cell ferroptosis will also be described. Finally, old drugs that can be repurposed to induce ferroptosis will be characterized, aiming for drug repurposing and novel drug combinations for cancer therapy more efficiently and economically.
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spelling pubmed-77720202021-01-08 The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors Zhu, Jinghan Xiong, Yixiao Zhang, Yuxin Wen, Jingyuan Cai, Ning Cheng, Kun Liang, Huifang Zhang, Wanguang Oxid Med Cell Longev Review Article Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system's failure. The sensitivity of ferroptosis is tightly regulated by a series of biological processes, the metabolism of iron, amino acids, and polyunsaturated fatty acids, and the interaction of glutathione (GSH), NADPH, coenzyme Q10 (CoQ10), and phospholipids. Elevated oxidative stress (ROS) level is a hallmark of cancer, and ferroptosis serves as a link between nutrition metabolism and redox biology. Targeting ferroptosis may be an effective and selective way for cancer therapy. The underlying molecular mechanism of ferroptosis occurrence is still not enough. This review will briefly summarize the process of ferroptosis and introduce critical molecules in the ferroptotic cascade. Furthermore, we reviewed the occurrence and regulation of reduction-oxidation (redox) for ferroptosis in cancer metabolism. The role of the tumor suppressor and the epigenetic regulator in tumor cell ferroptosis will also be described. Finally, old drugs that can be repurposed to induce ferroptosis will be characterized, aiming for drug repurposing and novel drug combinations for cancer therapy more efficiently and economically. Hindawi 2020-12-21 /pmc/articles/PMC7772020/ /pubmed/33425217 http://dx.doi.org/10.1155/2020/8810785 Text en Copyright © 2020 Jinghan Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhu, Jinghan
Xiong, Yixiao
Zhang, Yuxin
Wen, Jingyuan
Cai, Ning
Cheng, Kun
Liang, Huifang
Zhang, Wanguang
The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
title The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
title_full The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
title_fullStr The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
title_full_unstemmed The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
title_short The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
title_sort molecular mechanisms of regulating oxidative stress-induced ferroptosis and therapeutic strategy in tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772020/
https://www.ncbi.nlm.nih.gov/pubmed/33425217
http://dx.doi.org/10.1155/2020/8810785
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