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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy

Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other im...

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Autores principales: Dong, Zhaocheng, Liu, Zhiyuan, Dai, Haoran, Liu, Wenbin, Feng, Zhendong, Zhao, Qihan, Gao, Yu, Liu, Fei, Zhang, Na, Dong, Xuan, Zhou, Xiaoshan, Du, Jieli, Huang, Guangrui, Tian, Xuefei, Liu, Baoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772048/
https://www.ncbi.nlm.nih.gov/pubmed/33426094
http://dx.doi.org/10.1155/2020/7638365
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author Dong, Zhaocheng
Liu, Zhiyuan
Dai, Haoran
Liu, Wenbin
Feng, Zhendong
Zhao, Qihan
Gao, Yu
Liu, Fei
Zhang, Na
Dong, Xuan
Zhou, Xiaoshan
Du, Jieli
Huang, Guangrui
Tian, Xuefei
Liu, Baoli
author_facet Dong, Zhaocheng
Liu, Zhiyuan
Dai, Haoran
Liu, Wenbin
Feng, Zhendong
Zhao, Qihan
Gao, Yu
Liu, Fei
Zhang, Na
Dong, Xuan
Zhou, Xiaoshan
Du, Jieli
Huang, Guangrui
Tian, Xuefei
Liu, Baoli
author_sort Dong, Zhaocheng
collection PubMed
description Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions. For example, Br1 cells can secrete IgG4 to block autoantigens. Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. However, only a handful of studies have been done on the role of Bregs in this regard. In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN.
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spelling pubmed-77720482021-01-08 The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy Dong, Zhaocheng Liu, Zhiyuan Dai, Haoran Liu, Wenbin Feng, Zhendong Zhao, Qihan Gao, Yu Liu, Fei Zhang, Na Dong, Xuan Zhou, Xiaoshan Du, Jieli Huang, Guangrui Tian, Xuefei Liu, Baoli J Immunol Res Review Article Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions. For example, Br1 cells can secrete IgG4 to block autoantigens. Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. However, only a handful of studies have been done on the role of Bregs in this regard. In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN. Hindawi 2020-12-21 /pmc/articles/PMC7772048/ /pubmed/33426094 http://dx.doi.org/10.1155/2020/7638365 Text en Copyright © 2020 Zhaocheng Dong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dong, Zhaocheng
Liu, Zhiyuan
Dai, Haoran
Liu, Wenbin
Feng, Zhendong
Zhao, Qihan
Gao, Yu
Liu, Fei
Zhang, Na
Dong, Xuan
Zhou, Xiaoshan
Du, Jieli
Huang, Guangrui
Tian, Xuefei
Liu, Baoli
The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
title The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
title_full The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
title_fullStr The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
title_full_unstemmed The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
title_short The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
title_sort potential role of regulatory b cells in idiopathic membranous nephropathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772048/
https://www.ncbi.nlm.nih.gov/pubmed/33426094
http://dx.doi.org/10.1155/2020/7638365
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