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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other im...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772048/ https://www.ncbi.nlm.nih.gov/pubmed/33426094 http://dx.doi.org/10.1155/2020/7638365 |
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author | Dong, Zhaocheng Liu, Zhiyuan Dai, Haoran Liu, Wenbin Feng, Zhendong Zhao, Qihan Gao, Yu Liu, Fei Zhang, Na Dong, Xuan Zhou, Xiaoshan Du, Jieli Huang, Guangrui Tian, Xuefei Liu, Baoli |
author_facet | Dong, Zhaocheng Liu, Zhiyuan Dai, Haoran Liu, Wenbin Feng, Zhendong Zhao, Qihan Gao, Yu Liu, Fei Zhang, Na Dong, Xuan Zhou, Xiaoshan Du, Jieli Huang, Guangrui Tian, Xuefei Liu, Baoli |
author_sort | Dong, Zhaocheng |
collection | PubMed |
description | Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions. For example, Br1 cells can secrete IgG4 to block autoantigens. Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. However, only a handful of studies have been done on the role of Bregs in this regard. In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN. |
format | Online Article Text |
id | pubmed-7772048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-77720482021-01-08 The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy Dong, Zhaocheng Liu, Zhiyuan Dai, Haoran Liu, Wenbin Feng, Zhendong Zhao, Qihan Gao, Yu Liu, Fei Zhang, Na Dong, Xuan Zhou, Xiaoshan Du, Jieli Huang, Guangrui Tian, Xuefei Liu, Baoli J Immunol Res Review Article Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions. For example, Br1 cells can secrete IgG4 to block autoantigens. Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. However, only a handful of studies have been done on the role of Bregs in this regard. In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN. Hindawi 2020-12-21 /pmc/articles/PMC7772048/ /pubmed/33426094 http://dx.doi.org/10.1155/2020/7638365 Text en Copyright © 2020 Zhaocheng Dong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dong, Zhaocheng Liu, Zhiyuan Dai, Haoran Liu, Wenbin Feng, Zhendong Zhao, Qihan Gao, Yu Liu, Fei Zhang, Na Dong, Xuan Zhou, Xiaoshan Du, Jieli Huang, Guangrui Tian, Xuefei Liu, Baoli The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
title | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
title_full | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
title_fullStr | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
title_full_unstemmed | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
title_short | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
title_sort | potential role of regulatory b cells in idiopathic membranous nephropathy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772048/ https://www.ncbi.nlm.nih.gov/pubmed/33426094 http://dx.doi.org/10.1155/2020/7638365 |
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