Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism

We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4(+) T cells from DBA/2 mice into (C57BL/6 × DBA/2)F(1) (BDF1) mice. Although the protective effects were ascribed...

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Autores principales: Horwitz, David A., Liu, Aijing, Bickerton, Sean, Castaldo, Giuseppe, Matarese, Giuseppe, Fahmy, Tarek M., La Cava, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772200/
https://www.ncbi.nlm.nih.gov/pubmed/33391260
http://dx.doi.org/10.3389/fimmu.2020.583338
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author Horwitz, David A.
Liu, Aijing
Bickerton, Sean
Castaldo, Giuseppe
Matarese, Giuseppe
Fahmy, Tarek M.
La Cava, Antonio
author_facet Horwitz, David A.
Liu, Aijing
Bickerton, Sean
Castaldo, Giuseppe
Matarese, Giuseppe
Fahmy, Tarek M.
La Cava, Antonio
author_sort Horwitz, David A.
collection PubMed
description We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4(+) T cells from DBA/2 mice into (C57BL/6 × DBA/2)F(1) (BDF1) mice. Although the protective effects were ascribed to the induction of adaptive CD4(+) and CD8(+) T regulatory cells, the results suggested that another population of immune cells could be involved. Here we report that NK cells critically contribute to the protection from lupus-like disease conferred by NPs to BDF1 mice, and that this effect is TGF-β-dependent.
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spelling pubmed-77722002020-12-31 Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism Horwitz, David A. Liu, Aijing Bickerton, Sean Castaldo, Giuseppe Matarese, Giuseppe Fahmy, Tarek M. La Cava, Antonio Front Immunol Immunology We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4(+) T cells from DBA/2 mice into (C57BL/6 × DBA/2)F(1) (BDF1) mice. Although the protective effects were ascribed to the induction of adaptive CD4(+) and CD8(+) T regulatory cells, the results suggested that another population of immune cells could be involved. Here we report that NK cells critically contribute to the protection from lupus-like disease conferred by NPs to BDF1 mice, and that this effect is TGF-β-dependent. Frontiers Media S.A. 2020-12-16 /pmc/articles/PMC7772200/ /pubmed/33391260 http://dx.doi.org/10.3389/fimmu.2020.583338 Text en Copyright © 2020 Horwitz, Liu, Bickerton, Castaldo, Matarese, Fahmy and La Cava http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Horwitz, David A.
Liu, Aijing
Bickerton, Sean
Castaldo, Giuseppe
Matarese, Giuseppe
Fahmy, Tarek M.
La Cava, Antonio
Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
title Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
title_full Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
title_fullStr Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
title_full_unstemmed Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
title_short Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
title_sort anti-cd2 antibody-coated nanoparticles containing il-2 induce nk cells that protect lupus mice via a tgf-β-dependent mechanism
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772200/
https://www.ncbi.nlm.nih.gov/pubmed/33391260
http://dx.doi.org/10.3389/fimmu.2020.583338
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