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A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept

Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guideline...

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Detalles Bibliográficos
Autores principales:	Hartman, Stan J. F., Swaving, Joost G. E., van Beek, Stijn W., van Groen, Bianca D., de Hoop, Marika, van der Zanden, Tjitske M., ter Heine, Rob, de Wildt, Saskia N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772249/ https://www.ncbi.nlm.nih.gov/pubmed/33390970 http://dx.doi.org/10.3389/fphar.2020.592204

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