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Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila
Anise hyssop, Agastache foeniculum, is a widely used medicinal herb with known antioxidant properties. We studied how dietary supplementation with dried A. foeniculum leaf powder affected physiological and metabolic traits as well as activities of antioxidant enzymes and markers of oxidative stress...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772399/ https://www.ncbi.nlm.nih.gov/pubmed/33391017 http://dx.doi.org/10.3389/fphys.2020.596729 |
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author | Strilbytska, Olha M. Zayachkivska, Alina Koliada, Alexander Galeotti, Fabio Volpi, Nicola Storey, Kenneth B. Vaiserman, Alexander Lushchak, Oleh |
author_facet | Strilbytska, Olha M. Zayachkivska, Alina Koliada, Alexander Galeotti, Fabio Volpi, Nicola Storey, Kenneth B. Vaiserman, Alexander Lushchak, Oleh |
author_sort | Strilbytska, Olha M. |
collection | PubMed |
description | Anise hyssop, Agastache foeniculum, is a widely used medicinal herb with known antioxidant properties. We studied how dietary supplementation with dried A. foeniculum leaf powder affected physiological and metabolic traits as well as activities of antioxidant enzymes and markers of oxidative stress in Drosophila melanogaster. Dietary hyssop extended the lifespan in a sex and genotype independent manner over a broad range of concentrations up to 30 mg/ml. Dietary supplementation with the herb significantly increased fecundity, resistance to oxidative stress and starvation. Higher transcript levels of Drosophila insulin-like peptide (dilp2) and decreased dilp3 and dilp6 transcripts together with increased levels of glycogen and triacylglycerols support an alteration of insulin signaling by the plant extract. Increased enzymatic activities of superoxide dismutase and aconitase as well as elevated protein and low molecular mass thiols also supported an alteration of free radical process in flies treated with dietary A. foeniculum leaf powder. Thus, physiological and metabolic traits as well as free radical processed may be affected by active compounds detected in extracts of anise hyssop leaves and contribute to the increased lifespan and reproductive (egg-laying) activity observed. |
format | Online Article Text |
id | pubmed-7772399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77723992020-12-31 Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila Strilbytska, Olha M. Zayachkivska, Alina Koliada, Alexander Galeotti, Fabio Volpi, Nicola Storey, Kenneth B. Vaiserman, Alexander Lushchak, Oleh Front Physiol Physiology Anise hyssop, Agastache foeniculum, is a widely used medicinal herb with known antioxidant properties. We studied how dietary supplementation with dried A. foeniculum leaf powder affected physiological and metabolic traits as well as activities of antioxidant enzymes and markers of oxidative stress in Drosophila melanogaster. Dietary hyssop extended the lifespan in a sex and genotype independent manner over a broad range of concentrations up to 30 mg/ml. Dietary supplementation with the herb significantly increased fecundity, resistance to oxidative stress and starvation. Higher transcript levels of Drosophila insulin-like peptide (dilp2) and decreased dilp3 and dilp6 transcripts together with increased levels of glycogen and triacylglycerols support an alteration of insulin signaling by the plant extract. Increased enzymatic activities of superoxide dismutase and aconitase as well as elevated protein and low molecular mass thiols also supported an alteration of free radical process in flies treated with dietary A. foeniculum leaf powder. Thus, physiological and metabolic traits as well as free radical processed may be affected by active compounds detected in extracts of anise hyssop leaves and contribute to the increased lifespan and reproductive (egg-laying) activity observed. Frontiers Media S.A. 2020-12-16 /pmc/articles/PMC7772399/ /pubmed/33391017 http://dx.doi.org/10.3389/fphys.2020.596729 Text en Copyright © 2020 Strilbytska, Zayachkivska, Koliada, Galeotti, Volpi, Storey, Vaiserman and Lushchak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Strilbytska, Olha M. Zayachkivska, Alina Koliada, Alexander Galeotti, Fabio Volpi, Nicola Storey, Kenneth B. Vaiserman, Alexander Lushchak, Oleh Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila |
title | Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila |
title_full | Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila |
title_fullStr | Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila |
title_full_unstemmed | Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila |
title_short | Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila |
title_sort | anise hyssop agastache foeniculum increases lifespan, stress resistance, and metabolism by affecting free radical processes in drosophila |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772399/ https://www.ncbi.nlm.nih.gov/pubmed/33391017 http://dx.doi.org/10.3389/fphys.2020.596729 |
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