Progastrin production transitions from Bmi1(+)/Prox1(+) to Lgr5(high) cells during early intestinal tumorigenesis

Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expressed at small levels in the healthy intestinal mucosa, and its expression is enhanced at early stages of intestinal tumor development, with high levels of this peptide i...

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Detalles Bibliográficos
Autores principales: Giraud, J., Foroutan, M., Boubaker-Vitre, J., Grillet, F., Homayed, Z., Jadhav, U., Crespy, P., Breuker, C., Bourgaux, J-F., Hazerbroucq, J., Pignodel, C., Brulin, B., Shivdasani, R.A., Jay, P., Hollande, F., Pannequin, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772574/
https://www.ncbi.nlm.nih.gov/pubmed/33360299
http://dx.doi.org/10.1016/j.tranon.2020.101001

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