Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve

We investigated the diagnostic utility and safety of intracoronary bolus administration of nicorandil compared with intravenous administration of adenosine for evaluating FFR in patients with intermediate (40–70%) coronary stenosis. The FFR values obtained with nicorandil and adenosine showed linear...

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Autores principales: Chhabria, Rahul, Mehta, Nihar P., Jain, Nikesh, Handa, Sham R., Mehta, Ashwin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772593/
https://www.ncbi.nlm.nih.gov/pubmed/33357653
http://dx.doi.org/10.1016/j.ihj.2020.10.004
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author Chhabria, Rahul
Mehta, Nihar P.
Jain, Nikesh
Handa, Sham R.
Mehta, Ashwin B.
author_facet Chhabria, Rahul
Mehta, Nihar P.
Jain, Nikesh
Handa, Sham R.
Mehta, Ashwin B.
author_sort Chhabria, Rahul
collection PubMed
description We investigated the diagnostic utility and safety of intracoronary bolus administration of nicorandil compared with intravenous administration of adenosine for evaluating FFR in patients with intermediate (40–70%) coronary stenosis. The FFR values obtained with nicorandil and adenosine showed linear relationship. This correlation is statistically significant with regression coefficient of 0.932 (R2 = 0.834, p < 0.001). The side effects such as bronchospasm, hypotension, and bradycardia were significantly higher after administration of adenosine compared to nicorandil (20% vs. 1.66%, p = 0.001). Intracoronary use of nicorandil seems to be promising in offering the advantages of lesser side effects, similar efficacy, and lesser cost as compared to adenosine.
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spelling pubmed-77725932020-12-30 Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve Chhabria, Rahul Mehta, Nihar P. Jain, Nikesh Handa, Sham R. Mehta, Ashwin B. Indian Heart J Original Article We investigated the diagnostic utility and safety of intracoronary bolus administration of nicorandil compared with intravenous administration of adenosine for evaluating FFR in patients with intermediate (40–70%) coronary stenosis. The FFR values obtained with nicorandil and adenosine showed linear relationship. This correlation is statistically significant with regression coefficient of 0.932 (R2 = 0.834, p < 0.001). The side effects such as bronchospasm, hypotension, and bradycardia were significantly higher after administration of adenosine compared to nicorandil (20% vs. 1.66%, p = 0.001). Intracoronary use of nicorandil seems to be promising in offering the advantages of lesser side effects, similar efficacy, and lesser cost as compared to adenosine. Elsevier 2020 2020-10-20 /pmc/articles/PMC7772593/ /pubmed/33357653 http://dx.doi.org/10.1016/j.ihj.2020.10.004 Text en © 2020 Cardiological Society of India. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Chhabria, Rahul
Mehta, Nihar P.
Jain, Nikesh
Handa, Sham R.
Mehta, Ashwin B.
Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
title Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
title_full Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
title_fullStr Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
title_full_unstemmed Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
title_short Diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
title_sort diagnostic utility and safety of intracoronary nicorandil as a hyperemic agent for the measurement of fractional flow reserve
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772593/
https://www.ncbi.nlm.nih.gov/pubmed/33357653
http://dx.doi.org/10.1016/j.ihj.2020.10.004
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