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Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years
INTRODUCTION: The prevalence of airway allergies in Europe has increased from 23% to 31% in recent years. Polysensitization is associated with the development and severity of relevant allergies, particularly allergic asthma. OBJECTIVE: We investigated age- and sex-dependent monosensitization and pol...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772690/ https://www.ncbi.nlm.nih.gov/pubmed/33390729 http://dx.doi.org/10.2147/JAA.S280771 |
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author | Beutner, Caroline Forkel, Susann Gupta, Sidhi Fuchs, Thomas Schön, Michael P Geier, Johannes Buhl, Timo |
author_facet | Beutner, Caroline Forkel, Susann Gupta, Sidhi Fuchs, Thomas Schön, Michael P Geier, Johannes Buhl, Timo |
author_sort | Beutner, Caroline |
collection | PubMed |
description | INTRODUCTION: The prevalence of airway allergies in Europe has increased from 23% to 31% in recent years. Polysensitization is associated with the development and severity of relevant allergies, particularly allergic asthma. OBJECTIVE: We investigated age- and sex-dependent monosensitization and polysensitization profiles as well as patterns of sensitization using skin prick test (SPT) reactivity to the most common aeroallergens. PATIENTS AND METHODS: From 1998 to 2017, SPTs were retrospectively analyzed in 2886 symptomatic patients, referred to the University Medical Center Göttingen, located in central Germany. The major aeroallergen groups early flowering tree pollen, grass pollen, and house dust mites were evaluated in this study. Wheal diameters ≥2 mm were considered positive during the entire study period. RESULTS: Polysensitization to the most common aeroallergen groups increased significantly over 20 years. Boys and young men displayed the most remarkable rise in total sensitization rates in our study group over time. DISCUSSION: Our patient-based study demonstrates a continuing increase in polysensitization rates over the last 20 years, with boys and young men being most frequently affected. Our data—without being a population-based study—suggest a scenario with climbing rates of allergic rhinitis and asthma. |
format | Online Article Text |
id | pubmed-7772690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-77726902020-12-31 Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years Beutner, Caroline Forkel, Susann Gupta, Sidhi Fuchs, Thomas Schön, Michael P Geier, Johannes Buhl, Timo J Asthma Allergy Short Report INTRODUCTION: The prevalence of airway allergies in Europe has increased from 23% to 31% in recent years. Polysensitization is associated with the development and severity of relevant allergies, particularly allergic asthma. OBJECTIVE: We investigated age- and sex-dependent monosensitization and polysensitization profiles as well as patterns of sensitization using skin prick test (SPT) reactivity to the most common aeroallergens. PATIENTS AND METHODS: From 1998 to 2017, SPTs were retrospectively analyzed in 2886 symptomatic patients, referred to the University Medical Center Göttingen, located in central Germany. The major aeroallergen groups early flowering tree pollen, grass pollen, and house dust mites were evaluated in this study. Wheal diameters ≥2 mm were considered positive during the entire study period. RESULTS: Polysensitization to the most common aeroallergen groups increased significantly over 20 years. Boys and young men displayed the most remarkable rise in total sensitization rates in our study group over time. DISCUSSION: Our patient-based study demonstrates a continuing increase in polysensitization rates over the last 20 years, with boys and young men being most frequently affected. Our data—without being a population-based study—suggest a scenario with climbing rates of allergic rhinitis and asthma. Dove 2020-12-24 /pmc/articles/PMC7772690/ /pubmed/33390729 http://dx.doi.org/10.2147/JAA.S280771 Text en © 2020 Beutner et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Short Report Beutner, Caroline Forkel, Susann Gupta, Sidhi Fuchs, Thomas Schön, Michael P Geier, Johannes Buhl, Timo Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years |
title | Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years |
title_full | Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years |
title_fullStr | Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years |
title_full_unstemmed | Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years |
title_short | Sex- and Age-Dependent Changes in Polysensitization to Common Aeroallergens Over 20 Years |
title_sort | sex- and age-dependent changes in polysensitization to common aeroallergens over 20 years |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772690/ https://www.ncbi.nlm.nih.gov/pubmed/33390729 http://dx.doi.org/10.2147/JAA.S280771 |
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