Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than...

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Detalles Bibliográficos
Autores principales: Guthmiller, Jenna J., Lan, Linda Yu-Ling, Fernández-Quintero, Monica L., Han, Julianna, Utset, Henry A., Bitar, Dalia J., Hamel, Natalie J., Stovicek, Olivia, Li, Lei, Tepora, Micah, Henry, Carole, Neu, Karlynn E., Dugan, Haley L., Borowska, Marta T., Chen, Yao-Qing, Liu, Sean T.H., Stamper, Christopher T., Zheng, Nai-Ying, Huang, Min, Palm, Anna-Karin E., García-Sastre, Adolfo, Nachbagauer, Raffael, Palese, Peter, Coughlan, Lynda, Krammer, Florian, Ward, Andrew B., Liedl, Klaus R., Wilson, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772752/
https://www.ncbi.nlm.nih.gov/pubmed/33096040
http://dx.doi.org/10.1016/j.immuni.2020.10.005

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