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Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment
OBJECTIVES: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). METHODS: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772868/ https://www.ncbi.nlm.nih.gov/pubmed/33442392 http://dx.doi.org/10.1159/000511103 |
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author | Vintimilla, Raul Balasubramanian, Kishore Hall, James Johnson, Leigh O'Bryant, Sid |
author_facet | Vintimilla, Raul Balasubramanian, Kishore Hall, James Johnson, Leigh O'Bryant, Sid |
author_sort | Vintimilla, Raul |
collection | PubMed |
description | OBJECTIVES: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). METHODS: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50–86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. RESULTS: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. CONCLUSIONS: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia. |
format | Online Article Text |
id | pubmed-7772868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-77728682021-01-12 Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment Vintimilla, Raul Balasubramanian, Kishore Hall, James Johnson, Leigh O'Bryant, Sid Dement Geriatr Cogn Dis Extra Research Article OBJECTIVES: The present study sought to evaluate the contribution of cardiovascular risk factors to cognitive functioning in a sample of Mexican Americans diagnosed with mild cognitive impairment (MCI). METHODS: Hypertension, diabetes, dyslipidemia, and obesity were diagnosed based on self-report and/or standardized procedures. Cognitive function was measured with MMSE, Logical Memory I and II, Trail A & B, FAS, animal naming, and digit span tests. Independent samples t tests and two-way ANOVAs were conducted for analyses, adjusting for relevant covariates. We studied 100 Mexican Americans (65 female) with MCI, ages 50–86, from a longitudinal study of cognitive aging conducted at the University of North Texas Health Science Center. RESULTS: A difference between subjects with and without obesity and memory scores was shown by t tests. Two-way ANOVAs detected an association between the coexistence of hypertension and diabetes with language measures, diabetes and dyslipidemia with executive function, and diabetes and obesity with memory and language measures. CONCLUSIONS: This study provides additional evidence about the link between cardiovascular risk factors and cognitive dysfunction in MCI subjects, and also demonstrated that comorbid risk factors increased the degree of cognitive deficit in many areas, which may indicate a higher risk of developing dementia. S. Karger AG 2020-11-16 /pmc/articles/PMC7772868/ /pubmed/33442392 http://dx.doi.org/10.1159/000511103 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. |
spellingShingle | Research Article Vintimilla, Raul Balasubramanian, Kishore Hall, James Johnson, Leigh O'Bryant, Sid Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
title | Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
title_full | Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
title_fullStr | Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
title_full_unstemmed | Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
title_short | Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment |
title_sort | cardiovascular risk factors, cognitive dysfunction, and mild cognitive impairment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772868/ https://www.ncbi.nlm.nih.gov/pubmed/33442392 http://dx.doi.org/10.1159/000511103 |
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