Explore a novel function of human condensins in cellular senescence

There are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found wi...

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Detalles Bibliográficos
Autores principales: Wang, Hongzhen, Liu, Xin, Li, Guiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772929/
https://www.ncbi.nlm.nih.gov/pubmed/33375949
http://dx.doi.org/10.1186/s13578-020-00512-1
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author Wang, Hongzhen
Liu, Xin
Li, Guiying
author_facet Wang, Hongzhen
Liu, Xin
Li, Guiying
author_sort Wang, Hongzhen
collection PubMed
description There are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found with increasing evidences that they play important roles in cellular senescence. This paper reviewed the research progress of human condensins involved in different types of cellular senescence, mainly oncogene-induced senescence (OIS) and replicative senescence (RS). The future perspectives of human condensins involved in cellular senescence are also discussed.
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spelling pubmed-77729292020-12-30 Explore a novel function of human condensins in cellular senescence Wang, Hongzhen Liu, Xin Li, Guiying Cell Biosci Review There are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found with increasing evidences that they play important roles in cellular senescence. This paper reviewed the research progress of human condensins involved in different types of cellular senescence, mainly oncogene-induced senescence (OIS) and replicative senescence (RS). The future perspectives of human condensins involved in cellular senescence are also discussed. BioMed Central 2020-12-29 /pmc/articles/PMC7772929/ /pubmed/33375949 http://dx.doi.org/10.1186/s13578-020-00512-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Hongzhen
Liu, Xin
Li, Guiying
Explore a novel function of human condensins in cellular senescence
title Explore a novel function of human condensins in cellular senescence
title_full Explore a novel function of human condensins in cellular senescence
title_fullStr Explore a novel function of human condensins in cellular senescence
title_full_unstemmed Explore a novel function of human condensins in cellular senescence
title_short Explore a novel function of human condensins in cellular senescence
title_sort explore a novel function of human condensins in cellular senescence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772929/
https://www.ncbi.nlm.nih.gov/pubmed/33375949
http://dx.doi.org/10.1186/s13578-020-00512-1
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AT liuxin exploreanovelfunctionofhumancondensinsincellularsenescence
AT liguiying exploreanovelfunctionofhumancondensinsincellularsenescence

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