Emerging peptide antibiotics with therapeutic potential

This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear and macrocyclic peptide antibiotics, lipopeptides l...

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Detalles Bibliográficos
Autores principales: Upert, Gregory, Luther, Anatol, Obrecht, Daniel, Ermert, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773004/
https://www.ncbi.nlm.nih.gov/pubmed/33398258
http://dx.doi.org/10.1016/j.medidd.2020.100078
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author Upert, Gregory
Luther, Anatol
Obrecht, Daniel
Ermert, Philipp
author_facet Upert, Gregory
Luther, Anatol
Obrecht, Daniel
Ermert, Philipp
author_sort Upert, Gregory
collection PubMed
description This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear and macrocyclic peptide antibiotics, lipopeptides like the polymyxins as well as peptides addressing targets located in the plasma membrane or in the outer membrane of bacterial cells are discussed.
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spelling pubmed-77730042020-12-31 Emerging peptide antibiotics with therapeutic potential Upert, Gregory Luther, Anatol Obrecht, Daniel Ermert, Philipp Med Drug Discov Review Article This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear and macrocyclic peptide antibiotics, lipopeptides like the polymyxins as well as peptides addressing targets located in the plasma membrane or in the outer membrane of bacterial cells are discussed. The Authors. Published by Elsevier B.V. 2021-03 2020-12-30 /pmc/articles/PMC7773004/ /pubmed/33398258 http://dx.doi.org/10.1016/j.medidd.2020.100078 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Upert, Gregory
Luther, Anatol
Obrecht, Daniel
Ermert, Philipp
Emerging peptide antibiotics with therapeutic potential
title Emerging peptide antibiotics with therapeutic potential
title_full Emerging peptide antibiotics with therapeutic potential
title_fullStr Emerging peptide antibiotics with therapeutic potential
title_full_unstemmed Emerging peptide antibiotics with therapeutic potential
title_short Emerging peptide antibiotics with therapeutic potential
title_sort emerging peptide antibiotics with therapeutic potential
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773004/
https://www.ncbi.nlm.nih.gov/pubmed/33398258
http://dx.doi.org/10.1016/j.medidd.2020.100078
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